表现为环状肉芽肿的原发性皮肤弥漫性大B细胞淋巴瘤-腿型一例并文献复习  

Primary cutaneous diffuse large B-cell lymphoma, leg type, presenting as annular granuloma: a case report and literature review

作　　者：陈伟权 黄敬然 王蕾 方零露 周英 CHEN Weiquan;HUANG Jingran;WANG Lei;FANG Linglu;ZHOU Ying(Institute of Dermatology and Venereal Diseases,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China)

机构地区：[1]广东医科大学附属医院皮肤性病研究所,广东湛江524000

出　　处：《中国麻风皮肤病杂志》2025年第4期279-282,共4页China Journal of Leprosy and Skin Diseases

基　　金：中国高校产学研创新基金-新一代信息技术创新项目(编号:2023IT023);广东医科大学附属医院高层次人才科研启动项目(编号:GCC2023027)。

摘　　要：原发性皮肤弥漫性大B细胞淋巴瘤-腿型(PCDLBCL-LT)是一种罕见的皮肤B细胞淋巴瘤,具有较高的侵袭性和复发风险,本文报道一例。患者,男,47岁,右侧腰部环状红斑1个月。组织病理示大量异型淋巴细胞浸润,免疫组化CD20、CD79a、Bcl-2阳性,Ki-67增殖指数达80%。患者接受R-CHOP方案化疗五程后,皮损完全消退,随访2年半未见复发。本病例提示PCDLBCL-LT可能以环状肉芽肿样皮损为表现,易误诊,需结合病理和免疫组化确诊,并及时进行系统治疗以改善预后。Primary cutaneous diffuse large B-cell lymphoma-leg type(PCDLBCL-LT)is a rare form of skin B-cell lymphoma with a high risk of aggression and recurrence.We report a 47-year-old male with erythema annularis on the right lumbar for 1 month.Pathology showed a large number of heterogeneous lymphocyte infiltrates in the lesion,immunohistochemical CD20,CD79a,Bcl-2 positive,Ki-67 proliferation index up to 80%.After five courses of chemotherapy with R-CHOP regimen,the skin lesions completely subsided,and no recurrence was observed during the follow-up of two and a half years.This case suggests that PCDLBCL-LT may be manifested as annular granulomatous lesions,which is easy to misdiagnose.It is necessary to confirm the diagnosis by combining pathology and immunohistochemistry,and timely systematic treatment to improve the prognosis.

关 键 词：弥漫性大B细胞淋巴瘤 腿型 环状 利妥昔单抗 

分 类 号：R739.5[医药卫生—肿瘤]