Bifunctional TRPV1 Targeted Magnetothermal Switch to Attenuate Osteoarthritis Progression  

作　　者：Zhongyang Lv Peng Wang Weitong Li Ya Xie Wei Sun Xiaoyu Jin Ruiyang Jiang Yuxiang Fei Yuan Liu Tianshu Shi Hu Guo Ziying Sun Jintao Lin Xucai Wang Guihua Tan Yizhang Wu Nirong Bao Dongquan Shi 

机构地区：[1]Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China [2]Department of Orthopedics,Nanjing Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210002,China [3]Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine,321 Zhongshan Road,Nanjing 210008,Jiangsu,China [4]Department of orthopedic,The Jiangyin Clinical College of Xuzhou Medical University,Jiangyin 214400,China [5]Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University,321 Zhongshan Road,Nanjing 210008,Jiangsu,China [6]Co-Innovation Center for Efficient Processing and Utilization of Forest Resources,College of Chemical Engineering,Nanjing Forestry University,Nanjing,210037,China [7]Department of Applied Physical Sciences,The University of North Carolina at Chapel Hill,Chapel Hill,NC,USA

出　　处：《Research》2024年第4期252-265,共14页研究(英文)

基　　金：supported by National Science Foundation of China(82325035,82172481,32271409);Six Talent Peaks Project of Jiangsu Province(WSW-079);The Scientific Research Project of Jiangsu Commission of Health(LKZ2022011);Innovation Project of National Orthopedics and Sports Medicine Rehabilitation Clinical Medical Research Center(2021-NCRC-CXJJ-ZH-16);Jiangsu Funding Program for Excellent Postdoctoral Talent(2022ZB753);China Postdoctoral Science Foundation(2023M734292).

摘　　要：Transient receptor potential vanilloid family member 1(TRPV1)has been revealed as a therapeutic target of osteoarthritis(OA),the most common deteriorating whole joint disease,by impeding macrophagic inflammation and chondrocytes ferroptosis.However,the clinical application for capsaicin as the TRPV1 agonist is largely limited by its chronic toxicity.To address this issue,we developed a bifunctional controllable magnetothermal switch targeting TRPV1 for the alleviation of OA progression by coupling of magnetic nanoparticles(MNPs)to TRPV1 monoclonal antibodies(MNPs-TRPV1).Under the alternating magnetic field(AMF)stimulation,MNPs-TRPV1 locally dissipated heat,which was sufficient to trigger the opening and activation of TRPV1,and effectively impeded macrophagic inflammation and chondrocyte ferroptosis.This magnetothermal modulation of TRPV1 simultaneously attenuated synovitis and cartilage degeneration in mice incurred by destabilization of medial meniscus surgery,indicating the delayed OA progression.

关 键 词：TRPV1 inflammation stimulation 

分 类 号：R57[医药卫生—消化系统]