猪肠道冠状病毒的致病机制研究进展  

Research progress on pathogenesis of swine enteric coronaviruses

作　　者：谷九龙 黄石磊 尹艳玲 GU Jiulong;HUANG Shilei;YIN Yanling(College of Animal Science and Technology,Chongqing Three Gorges Vocational College,Wanzhou,Chongqing 404155,China)

机构地区：[1]重庆三峡职业学院动物科技学院,重庆万州404155

出　　处：《中国兽医学报》2024年第12期2667-2672,共6页Chinese Journal of Veterinary Science

基　　金：重庆市教育委员会科学技术研究资助项目(KJQN202303516);重庆市万州区博士直通车科研资助项目(wzstc20230417);重庆市教育委员会科学技术研究资助项目(KJQN202203513);重庆三峡职业学院重点科研资助项目(cqsx2021001)。

摘　　要：猪肠道冠状病毒(SeCoVs)是导致新生仔猪急性致死性腹泻的常见病原体,主要包括传染性胃肠炎病毒(TGEV)、猪流行性腹泻病毒(PEDV)、猪德尔塔冠状病毒(PDCoV)和猪急性腹泻综合征冠状病毒(SADS-CoV)。TGEV和PEDV已在猪群中传播长达几十年而仍未得到有效的控制,而新发的PDCoV和SADS-CoV不仅对仔猪具有高致病性,且存在跨物种传播风险。尽管有许多针对TGEV和PEDV的商业化疫苗,但它们仍广泛传播,而目前尚缺乏预防PDCoV和SADS-CoV感染的疫苗,因此明确SeCoVs的致病机制则显得至关重要。现综述SeCoVs入侵宿主细胞及其免疫逃逸机制的最新研究进展,旨在为SeCoVs的防控提供参考。Swine enteric coronaviruses(SeCoVs),including transmissible gastroenteritis virus(TGEV),porcine epidemic diarrhea virus(PEDV),porcine deltacoronavirus(PDCoV)and swine acute diarrhea syndrome coronavirus(SADS-CoV),are common pathogens that cause acute lethal diarrhea in neonatal piglets.TGEV and PEDV have been circulating among swine for decades without effective control.The recent emergence of PDCoV and SADS-CoV are not only highly pathogenic to neonatal piglets,but also pose a risk of cross-species transmission.Despite the availability of many commercial vaccines against TGEV and PEDV,they remain widespread,and there are currently no vaccines available for PDCoV and SADS-CoV.Therefore,it is crucial to elucidate the pathogenesis of SeCoVs.This review describes recent developments in the invasion and immune evasion mechanisms of SeCoVs,and attempts to provide references for prevention and control of SeCoVs.

关 键 词：猪肠道冠状病毒 致病机制 入侵机制 免疫逃逸 

分 类 号：S852.65[农业科学—基础兽医学]