Gallstones,cholecystectomy,and cancer risk:an observational and Mendelian randomization study  

作　　者：Yuanyue Zhu Linhui Shen Yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li Yan Guijun Qin Xulei Tang Gang Chen Yu Xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang Feixia Shen Xuejiang Gu Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Shengli Wu Tao Yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Weiqing Wang Guang Ning Jieli Lu Min Xu Yufang Bi Weiguo Hu 

机构地区：[1]Department of Geriatrics,Medical Center on Aging,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [2]Jiangxi Provincial People's Hospital Afiliated to Nanchang University,Nanchang 330006,China [3]The Afiliated Hospital of Southwest Medical University,Luzhou 646000,China [4]The First Afiliated Hospital of Guangxi Medical University,Nanning 530021,China [5]Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China [6]Afiliated Hospital of Guizhou Medical University,Guiyang 550004,China [7]Xinhua Hospital Afiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China [8]Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China [9]Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 5i0120,China [10]The First Afiliated Hospital of Zhengzhou University,Zhengzhou 450052,China [11]The First Hospital of Lanzhou University,Lanzhou 730000,China [12]Fujian Provincial Hospital,Fujian Medical University,Fuzhou 350003,China [13]Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital Afiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [14]Shanghai National Clinicai Research Center for metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China,Shanghai Key Laboratory for Endocrine Tumor,State Key Laboratory of Medical Genomics,Ruijin Hospital Afiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [15]Dalian Municipal Central Hospital Afiliated of Dalian Medical University,Dalian 116033,China [16]The First Hospital of Jilin University,Changchun 130021,China [17]The First Afiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China [18]Qilu Hospital of Shandong University,Jinan 250012,China [19]The Second Afiliated Hospital of Harbin Medical University,Harbin 150086,China [20]Central Hospital of Shanghai Ji

出　　处：《Frontiers of Medicine》2025年第1期79-89,共11页医学前沿(英文版)

基　　金：funded by the National Natural Science Foundation of China(Nos.82270859,82370819,and 82088102);the National Key R&D Program of China(No.2023YFC2506700);the Shanghai Municipal Government grant(No.22Y31900300);the Shanghai Clinical Research Center for Metabolic Diseases(No.19MC1910100).

摘　　要：This study aimed to comprehensively examine the association of gallstones,cholecystectomy,and cancer risk.Multivariable logistic regressions were performed to estimate the observational associations of gallstones and cholecystectomy with cancer risk,using data from a nationwide cohort involving 239799 participants.General and gender-specific two-sample Mendelian randomization(MR)analysis was further conducted to assess the causalities of the observed associations.Observationally,a history of gallstones without cholecystectomy was associated with a high risk of stomach cancer(adjusted odds ratio(aOR)=2.54,95%confidence interval(CI)1.50–4.28),liver and bile duct cancer(aOR=2.46,95%CI 1.17–5.16),kidney cancer(aOR=2.04,95%CI 1.05–3.94),and bladder cancer(aOR=2.23,95%CI 1.01–5.13)in the general population,as well as cervical cancer(aOR=1.69,95%CI 1.12–2.56)in women.Moreover,cholecystectomy was associated with high odds of stomach cancer(aOR=2.41,95%CI 1.29–4.49),colorectal cancer(aOR=1.83,95%CI 1.18–2.85),and cancer of liver and bile duct(aOR=2.58,95%CI 1.11–6.02).MR analysis only supported the causal effect of gallstones on stomach,liver and bile duct,kidney,and bladder cancer.This study added evidence to the causal effect of gallstones on stomach,liver and bile duct,kidney,and bladder cancer,highlighting the importance of cancer screening in individuals with gallstones.

关 键 词：GALLSTONE CHOLECYSTECTOMY cancer risk Mendelian randomization 

分 类 号：R73[医药卫生—肿瘤]