Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer  

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作  者:Xueyan Shi Sichong Han Guizhen Wang Guangbiao Zhou 

机构地区:[1]State Key Laboratory of Molecular Oncology&Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China

出  处:《Frontiers of Medicine》2025年第1期101-120,共20页医学前沿(英文版)

基  金:supported by the National Key Research and Development Program of China(Nos.2023YFC3503205 and 2022YFA1103900);the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2022-I2M-1-009);the National Natural Science Foundation of China(Nos.22372944,22073092 nnd 82273076);the Science and Technology Research Project of Henan Province(No.222122316366);the Henan Provincial Medical Science and Technology Research Project(No.LHGJ20210183);the Scientific Research Fund Project of the Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital.

摘  要:Mitochondria are the convergence point of multiple pathways that trigger programmed cell death(PCD).Mitochondrial-associated PCD(mtPCD)is involved in the pathogenesis of several diseases.However,the role of mtPCD in the prognostic prediction of cancers including non-small-cell lung cancer(NSCLC)remains to be investigated.Here,12 mtPCD patterns were analyzed in transcriptomics,genomics,and clinical data collected from 4 datasets containing 977 patients.A risk-score assessment system containing 18 genes was established.We found that NSCLC patients with a high-risk score had a poorer prognosis.A nomogram was constructed by incorporating the risk score with clinical features.The risk score was further associated with clinicopathological information,tumor-mutation frequency,and immunotherapy responses.NSCLC patients with a high risk score had more Treg cells infiltration.However,these patients had higher tumor-mutation burden scores and may be more sensitive to immunotherapy.Moreover,receptor-interacting serine/threonine protein kinase 2(RIPK2)was selected from mtPCD gene model for validation.We found that RIPK2 exhibited oncogenic function,and its expression level was inversely associated with the overall survival of NSCLC.Taken together,our results indicated the accuracy and practicability of the mtPCD gene model and RIPK2 in predicting the prognosis of NSCLC.

关 键 词:mitochondrial associated programmed cell death NSCLC PROGNOSIS gene signature 

分 类 号:R73[医药卫生—肿瘤]

 

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