中药治疗溃疡性结肠炎的研究进展  

Research progress in treatment of ulcerative colitis with traditional Chinese medicine

作　　者：郑文心 李红 马辰 王琴 顾健 ZHENG Wen-xin;LI Hong;MA Chen;WANG Qin;GU Jian(College of Pharmacy,Southwest Minzu University,Chengdu 610041,China)

机构地区：[1]西南民族大学药学院,四川成都610041

出　　处：《中国中药杂志》2025年第4期860-873,共14页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81573563,82302970);西南民族大学青藏高原科研团队项目(2024CXTD16);四川省中医药管理局科研团队项目(2023ZD05)。

摘　　要：溃疡性结肠炎(ulcerative colitis,UC)是一种病因复杂且容易复发的慢性非特异性炎性疾病。迄今,临床使用的西药治疗效果不佳,并常伴有不良反应。因此,中药多靶点、多层次、协同和异质性的特点,更有利于UC的治疗。肠道菌群作为最大的微生物群之一,与人体健康和疾病密切相关。肠道菌群一旦失调,就会影响肠黏膜屏障的完整性,从而加重UC。而信号通路的异常激活可能导致炎症反应失调,并在UC发病机制中起重要作用。研究表明,单味中药及复方可以通过调节肠道菌群及信号通路,进一步保护肠道屏障和免疫系统功能,达到治疗UC的效果。该文综述了近年来国内外有关单味中药及复方调控肠道菌群及相关信号通路治疗UC的最新研究成果,以期为中药治疗UC临床实践和相关新药研发提供一定的理论参考。Ulcerative colitis(UC)is a chronic,non-specific inflammatory disease with a complex etiology and a tendency for recurrence.So far,the clinical efficacy of western medicine in treating UC has been poor and is often accompanied by adverse reactions.Therefore,the multi-target,multi-level,synergistic,and heterogeneous characteristics of traditional Chinese medicine(TCM)are more beneficial for the treatment of UC.As one of the largest microbiotas,the intestinal flora is closely related to human health and disease.Once the intestinal flora becomes dysfunctional,it can affect the integrity of the intestinal mucosal barrier,thereby exacerbating UC.Additionally,the abnormal activation of signaling pathways may lead to dysregulation of the inflammatory response and play an important role in the pathogenesis of UC.Many studies have shown that individual TCMs and their compounds can further protect the intestinal barrier and immune system function by regulating the intestinal flora and associated signaling pathways,achieving therapeutic effects for UC.This paper summarizes the latest research results in China and abroad on the regulation of intestinal flora and related signaling pathways by individual TCMs and compounds in the treatment of UC,aiming to provide theoretical references for the clinical practice of TCM in treating UC and for related new drug research and development.

关 键 词：溃疡性结肠炎 中药 肠道菌群 信号通路 

分 类 号：R57[医药卫生—消化系统]