肿瘤内微生物与肿瘤演进及相关抗肿瘤治疗策略研究进展  

Research Progress on Intratumoral Microbiota,Tumor Progression and Relevant Antitumor Strategies

作　　者：冯森语 柳娜[1] FENG Senyu;LIU Na(State Key Laboratory of Oncology in South China,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]华南恶性肿瘤防治全国重点实验室,广东省鼻咽癌诊治研究重点实验室,广东省恶性肿瘤临床医学研究中心,中山大学肿瘤防治中心,广州510060

出　　处：《中国细胞生物学学报》2025年第3期353-368,共16页Chinese Journal of Cell Biology

基　　金：国家自然科学基金面上项目(批准号:82372592);中山大学肿瘤防治中心杰出青年人才培养计划(批准号:YTP-SYSUCC-0010)资助的课题。

摘　　要：数以亿计的微生物长期定植于人体众多生态位中。这些微生物对人体各种生理活动的有序进行及整体健康状态的维持有着极为重要的意义,也与包括肿瘤在内的多种人体疾病的发生发展有着密切关系。随着微生物组学技术的发展,肿瘤内微生物群的概念逐步得到确立,针对宿主、肿瘤内微生物群与肿瘤间复杂关系的研究也日渐深入。该文系统性地总结了肿瘤内细菌、真菌及病毒对多种肿瘤演进的影响,并汇总论述了多种以肿瘤内微生物群为靶点的新型抗肿瘤治疗策略。此外,该文也进一步讨论了现阶段肿瘤内微生物群研究存在的一些问题,并提出该领域未来可能的研究方向。Trillions of microorganisms colonize various ecological niches within the human body.These microorganisms are crucial for numerous physiological activities and the maintenance of the overall health of the human.They are also closely associated with the occurrence and development of various diseases,including cancer.With advancements in microbiomic technologies,the concept of intratumoral microbiota has been gradually established.Insightful studies are currently underway to unravel the complex interactions among human body,intratumoral microbiota,and tumors.This article reviews the effects of intratumoral bacteria,fungi,and viruses on the progression of various types of cancer.It also provides a comprehensive discussion on the cutting-edge anti-tumor therapeutic strategies targeting the intratumoral microbiota.Additionally,it discusses the limitations of current research and provides insights for future research.

关 键 词：肿瘤内微生物群 基因组损伤 表观遗传修饰 促癌信号通路 肿瘤免疫微环境 药物代谢 肿瘤治疗 

分 类 号：R73[医药卫生—肿瘤]