RNA甲基化与肿瘤染色质重塑  

RNA Methylation and Chromatin Remodeling in Cancer

作　　者：叶灿彬 张嘉良 林东昕 郑健 YE Canbin;ZHANG Jialiang;LIN Dongxin;ZHENG Jian(State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]华南恶性肿瘤防治全国重点实验室,广东省恶性肿瘤临床医学研究中心,中山大学肿瘤防治中心,广州510060

出　　处：《中国细胞生物学学报》2025年第3期379-392,共14页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:82325037、82072617、82003162)资助的课题。

摘　　要：表观遗传重编程在癌症发展中扮演着关键角色,其中RNA的N^(6)-甲基腺嘌呤(m^(6)A)甲基化修饰与染色质重塑之间的相互作用对肿瘤演进具有重要影响。该文综述了RNA m^(6)A甲基化与染色质重塑之间的相互作用,包括m^(6)A写入对染色质重塑的影响、RNA m^(6)A如何通过影响DNA甲基化和组蛋白修饰调控染色质状态以及RNA m^(6)A对染色质三维结构的调控作用。同时,该文探讨了染色质重塑如何调控RNA m^(6)A修饰,包括对RNA m^(6)A相关因子表达及功能的影响。这些相互作用在肿瘤的发生、发展以及治疗反应中发挥着关键的调控作用。Epigenetic reprogramming plays a crucial role in the development of cancer,where the interplay between RNA m^(6)A(N^(6)-methyladenosine)methylation modification and chromatin remodeling has a significant impact on tumor progression.This review summarizes the interactions between m^(6)A modification and chromatin remodeling,including the impact of co-transcriptional m^(6)A incorporation on chromatin remodeling,how RNA m^(6)A regulates chromatin status by affecting DNA methylation and histone modifications,and the regulatory role of RNA m^(6)A on the three-dimensional structure of chromatin.Additionally,it discusses how chromatin remodeling can reciprocally regulate RNA m^(6)A modification,including its effects on the expression and function of RNA m^(6)A-related factors.These interactions play a key regulatory role in the occurrence,development,and therapeutic response of tumors.

关 键 词：RNA甲基化 染色质重塑 N^(6)-甲基腺嘌呤 组蛋白修饰 DNA甲基化 

分 类 号：R73[医药卫生—肿瘤]