靶向肿瘤硬度:从实验到临床  

Targeting on the Tumor Stiffness:from Bench to Bed

作　　者：邓慧琳 王南舟 吴海燕[1] 王子超 康巍瀚 申颖 DENG Huilin;WANG Nanzhou;WU Haiyan;WANG Zichao;KANG Weihan;SHEN Ying(State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]华南恶性肿瘤防治全国重点实验室,广东省恶性肿瘤临床医学研究中心,中山大学肿瘤防治中心,广州510060

出　　处：《中国细胞生物学学报》2025年第3期512-533,共22页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:82273314)资助的课题。

摘　　要：近年来,生物力学在肿瘤研究中的重要性逐渐被认识,肿瘤的发生和进展不仅受到遗传变异和分子信号通路的影响,还与其力学变化密切相关。细胞外基质(ECM)的硬度等物理特征能够通过力敏分子调控肿瘤细胞的行为,进而影响肿瘤发展、转移和治疗效果。生物力学的研究不仅为理解肿瘤的复杂性提供了新视角,还为未来的肿瘤治疗开辟了新思路,特别是通过调控力学环境或靶向力学信号分子来抑制肿瘤进展并提高治疗效果。该综述旨在探讨肿瘤生物力学特征在肿瘤发展、转移及治疗抵抗中的作用,分析肿瘤组织硬度、细胞刚性及相关信号通路的调控机制,并探讨这些因素在肿瘤治疗中的潜在应用。In recent years,the importance of biomechanics in tumor research has been increasingly recognized.Studies have shown that tumor initiation and progression are not only influenced by genetic mutations and molecular signaling pathways but are also closely related to mechanical changes.The physical properties of the ECM(extracellular matrix):such as stiffness,can regulate tumor cell behavior through mechanosensitive molecules,thereby affecting tumor development,metastasis,and therapeutic outcomes.Research in biomechanics provides a new perspective for understanding tumor complexity and opens new avenues for cancer treatment,particularly by modulating the mechanical environment or targeting mechanosensitive molecules to inhibit tumor progression and enhance treatment efficacy.This review explores the role of tumor biomechanical characteristics in tumor progression,metastasis,and treatment resistance,analyzing regulatory mechanisms of tissue stiffness,cellular stiffness,and related signaling pathways,and discusses the potential applications of these factors in cancer therapy.

关 键 词：生物力学 肿瘤 细胞外基质 力学信号 肿瘤治疗 

分 类 号：R73[医药卫生—肿瘤]