细胞应激在结直肠癌中的研究进展  

Research Progress of Cellular Stress in Colorectal Cancer

作　　者：徐水丹 蔡小霞 吕永瑞 王凤伟 谢丹[1] XU Shuidan;CAI Xiaoxia;LÜYongrui;WANG Fengwei;XIE Dan(State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]华南恶性肿瘤防治全国重点实验室,广东省恶性肿瘤临床医学研究中心,中山大学肿瘤防治中心,广州510060

出　　处：《中国细胞生物学学报》2025年第3期598-610,共13页Chinese Journal of Cell Biology

基　　金：国家自然科学基金面上项目(批准号:82372620、82072608)资助的课题。

摘　　要：结直肠癌是我国最常见的恶性肿瘤之一,且发病率呈逐渐上升之势。结直肠癌突变率高、驱动基因多、分型多样、异质性高等特点,导致其对放化疗及免疫治疗响应率低、晚期预后差。应激耐受是肿瘤细胞在发生发展过程中逐步重塑、适应环境、维持生存所共有的重要特征。揭示结直肠癌肿瘤细胞应激耐受的机制,可为提高预防和治疗的有效率提供新策略和靶点。该文结合国内外研究进展,对肿瘤细胞应激耐受在结直肠癌发生发展中的作用及机制进行综述。CRC(colorectal cancer)is one of the most common malignant tumors in China,and its incidence rate is gradually rising.The high mutation rate,multiple driver genes,diverse subtypes,and high heterogeneity of CRC lead to low response rates to radiotherapy,chemotherapy,and immunotherapy,as well as poor prognosis in the late stage.Stress tolerance is an important characteristic of tumor cells as they gradually adapt to the microenvironment and maintain survival during the development of CRC.Revealing the mechanism of stress tolerance in CRC tumor cells can provide new strategies and targets for improving the effectiveness of prevention and treatment.This study reviews the role and mechanism of tumor cell stress tolerance in the pathogenesis of CRC.

关 键 词：结直肠癌 应激耐受 氧化应激 复制应激 内质网应激 应激颗粒 

分 类 号：R73[医药卫生—肿瘤]