PAX1基因甲基化在宫颈病变诊疗中的应用价值  

The value of PAX1 gene methylation in the diagnosis and treatment of cervical lesions

作　　者：张颖[1] 陈帅 张丽娜 ZHANG Ying;CHEN Shuai;ZHANG Lina(Changzhou Maternal and Child Health Hospital,Changzhou Medical Center,Nanjing Medical University,Changzhou Key Laboratory of Maternal and Child Health Medicine,Changzhou 213003,China)

机构地区：[1]南京医科大学常州医学中心常州市妇幼保健院,常州市妇幼医学重点实验室,江苏常州213003

出　　处：《南京医科大学学报(自然科学版)》2025年第4期471-477,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省妇幼健康科研项目(F202166);常州市政策引导类计划项目(CZ20230020);常州医学中心科研项目(CMCC202314);常州市“十四五”卫生健康高层次人才培养工程—领军人才(CZLJ2022030);南京医科大学科技发展(NMUB2020075)。

摘　　要：宫颈癌作为全球妇女第四大常见癌症,在低收入和中等收入国家中发病率更高。其发生与人乳头瘤病毒(human papillomavirus,HPV)感染密切相关。文章通过深入分析和综合相关文献,指出配对盒1(paired box 1,PAX1)基因的甲基化状态可以作为宫颈癌早期诊断的重要标志物。相比传统方法,PAX1甲基化状态检测宫颈癌特异度和灵敏度高,为宫颈癌的早期发现提供了新的可能。同时PAX1基因的甲基化状态还可用于评估宫颈癌治疗后的预后情况。在宫颈癌的发病机制中,PAX1基因启动子区高甲基化导致其表达显著下调,此变化既削弱PAX1生理功能,又干扰细胞增殖与分化调控。此外,PAX1基因甲基化联合其他生物标志物检测可大幅提升宫颈癌筛查的准确性与灵敏度。尽管目前PAX1甲基化的研究受临床样本量少、研究周期短等因素制约,但其在宫颈癌的诊治中已展现出重要作用和广泛的应用潜力。随着技术的不断发展和研究的深入,PAX1甲基化有望成为宫颈癌早期筛查及个性化治疗的重要手段。Cervical cancer,the fourth most common cancer among women worldwide,is more significant and prevalent,especially in low-and middle-income countries.Its occurrence is closely related to human papillomavirus(HPV)infection.Through in-depth analysis and synthesis of related literature,this review indicates that the methylation status of the paired box 1(PAX1)gene can be used as an important marker for the early diagnosis of cervical cancer.Compared with traditional methods,PAX1 methylation status demonstrated more excellent specificity and sensitivity,providing new possibilities for the early detection of cervical cancer.Meanwhile,it was also found that the methylation status of PAX1 gene can also be used to assess the prognosis of cervical cancer after treatment.In the pathogenesis of cervical cancer,hypermethylation of the promoter region of the PAX1 gene leads to a significant down-regulation of its expression,which not only weakens the physiological function of PAX1,but also interferes with the normal regulation of cell proliferation and differentiation.In addition,the combination of PAX1 gene methylation and other biomarkers can significantly improve the accuracy and sensitivity of cervical cancer screening.Although the current research on PAX1 methylation is constrained by factors such as small clinical sample size and short research period,it has shown an important role and wide application potential in the diagnosis and treatment of cervical cancer.With the continuous development of technology and in-depth research,PAX1 methylation is expected to become an important tool for early screening and personalized treatment of cervical cancer.

关 键 词：PAX1 甲基化 宫颈癌 机制 

分 类 号：R737.33[医药卫生—肿瘤]