LCN2在神经系统疾病中作用机制研究进展  

Research Progress on the Mechanism of Lipocalin⁃2 in Neurological Diseases

作　　者：周永泰 杨朕钰 李岩[1,2] 吴嘉静 赵波 ZHOU Yongtai;YANG Zhenyu;LI Yan;WU Jiajing;ZHAO Bo(The First Clinical Medical College of Gansu University of Traditional Chinese Medicine,Lanzhou 730030,China;Department of Neurology,The 940th Hospital of Joint Logistics Support Force of Chinese Peoples Liberation Army,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730030 [2]联勤保障部队第九四〇医院神经内科,兰州730050

出　　处：《协和医学杂志》2025年第2期330-337,共8页Medical Journal of Peking Union Medical College Hospital

基　　金：联勤保障部队第九四〇医院研究生导师专项(2022YXKY012,2023YXKY008);兰州市科技计划项目(2024-9-141)。

摘　　要：脂质运载蛋白2(lipocalin-2,LCN2)是人脂质运载蛋白家族的一员,已被证明与糖尿病、心血管疾病、肾脏疾病存在密切关联。近年来研究表明,LCN2通过介导炎症、氧化应激反应、铁死亡等路径在多种神经系统疾病的发生发展中发挥重要调节作用。本文从脑血管疾病、认知障碍性疾病、帕金森病、抑郁症及焦虑症等方面,阐述LCN2在神经系统疾病中作用机制,以期加深临床的认知。Lipocalin⁃2(LCN2),a member of the human lipocalin family,has been demonstrated to be closely associated with diabetes,cardiovascular diseases,and renal disorders.Recent studies have indicated that LCN2 plays a significant regulatory role in the pathogenesis and progression of various neurological diseases by medi⁃ating pathways such as inflammation,oxidative stress,and ferroptosis.This article reviews the research advancements on the mechanism of LCN2 in neurological disorders,including cerebrovascular diseases,cognitive impairment disor⁃ders,Parkinson's disease,depression,and anxiety disorders,aiming to enhance clinical understanding.

关 键 词：脂质运载蛋白2 脑血管疾病 认知障碍性疾病 神经退行性疾病 焦虑症 抑郁症 

分 类 号：R742[医药卫生—神经病学与精神病学] R364[医药卫生—临床医学]