线粒体自噬与血管性认知障碍的相关性研究进展  

Research Progress on the Correlation Between Mitophagy and Vascular Cognitive Impairment

作　　者：刘艳 董新刚[2] 王晓元[1] 齐格格 任艺芹 周连鹏 李慧 张素清 李伟峰 LIU Yan;DONG Xingang;WANG Xiaoyuan;QI Gege;REN Yiqin;ZHOU Lianpeng;LI Hui;ZHANG Suqing;LI Weifeng(Rehabilitation Medicine College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Encephalopathy,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学康复医学院,郑州450046 [2]河南中医药大学第一附属医院脑病科,郑州450000

出　　处：《协和医学杂志》2025年第2期338-349,共12页Medical Journal of Peking Union Medical College Hospital

基　　金：河南省中医药科学研究专项课题(2024ZY1006,2024ZY1068);河南省中医药科学研究专项课题重大专项(2022ZYZD05);河南省科技发展计划(242102310514);第七批全国名老中医药专家学术经验继承工作项目(豫中医函[2022]3号);河南中医药大学2024年度研究生科研能力提升计划(2024KYCX086)。

摘　　要：血管性认知障碍是由脑血管问题导致的认知功能受损,严重影响老年人的生活质量,但目前缺乏有效的治疗方法。线粒体自噬是一种线粒体自我清除机制,是近年来神经系统疾病研究的热点机制。大量研究表明,线粒体自噬能够调节氧化应激、神经炎症,影响神经元凋亡,其相关信号通路,如PINK/Parkin、BNIP3/Nip和FUNDC1受体、PI3K/Akt/mTOR以及AMPK通路,已成为治疗血管性认知障碍的潜在靶点。本文围绕线粒体自噬在血管性认知障碍中的作用机制以及潜在治疗策略进行阐述,以期为临床治疗提供新思路。Vascular cognitive impairment(VCI),caused by cerebrovascular dysfunction,severely im⁃pacts the quality of life in the elderly population,yet effective therapeutic approaches remain limited.Mitoph⁃agy,a selective mitochondrial quality⁃control mechanism,has emerged as a critical focus in neurological disease research.Accumulating evidence indicates that mitophagy modulates oxidative stress,neuroinflammation,and neuronal apoptosis.Key signaling pathways associated with mitophagy-including PINK1/Parkin,BNIP3/Nix,FUNDC1,PI3K/Akt/mTOR,and AMPK-have been identified as potential therapeutic targets for VCI.This review summarizes the mechanistic roles of mitophagy in VCI pathogenesis and explores emerging therapeutic strategies targeting these pathways,aiming to provide novel insights for clinical intervention and advance the development of effective treatments for VCI.

关 键 词：血管性认知障碍 线粒体自噬 信号通路 治疗 研究进展 

分 类 号：R745.1[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]