白细胞介素-6与肠易激综合征:机制与研究进展  

Interleukin⁃6 and Irritable Bowel Syndrome:Mechanisms and Research Advances

作　　者：刘莉 赵春华 闵寒[1,2] LIU Li;ZHAO Chunhua;MIN Han(Department of Gastroenterology,The Affiliated Suzhou Hospital of Nanjing Medical University(Suzhou Municipal Hospital,Suzhou Women and Children's Heath Hospital),Suzhou,Jiangsu 215001,China;Medical Big Data Center,The Affiliated Suzhou Hospital of Nanjing Medical University(Suzhou Municipal Hospital,Suzhou Women and Children's Heath Hospital),Suzhou,Jiangsu 215001,China)

机构地区：[1]南京医科大学附属苏州医院(苏州市立医院,苏州市妇幼保健院)消化内科,江苏苏州215001 [2]南京医科大学附属苏州医院(苏州市立医院,苏州市妇幼保健院)医疗大数据中心,江苏苏州215001

出　　处：《协和医学杂志》2025年第2期431-438,共8页Medical Journal of Peking Union Medical College Hospital

基　　金：苏州市姑苏卫生人才计划(GSWS2021041)。

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)是一种极为常见的慢性肠道疾病,以反复发作的腹痛和排便习惯改变为主要临床表现,严重影响患者的生活质量。目前IBS病因尚未完全明确,研究发现以促炎细胞因子与抗炎细胞因子失衡为主要表现的肠道低度炎症和免疫激活是IBS的重要发病机制。其中,白细胞介素(interleukin,IL)-6作为一种核心的促炎细胞因子,在IBS患者中表达显著升高,其可通过改变个体对IBS易感性、促进胃肠道运动与分泌、激活下丘脑-垂体-肾上腺轴、诱导内脏高敏感及肠道黏膜屏障功能障碍等机制参与IBS发病,并与病情严重程度密切相关。本文就IL-6在IBS中的作用机制作一综述,以期为临床工作者开展IBS病因学研究提供借鉴和参考。Irritable bowel syndrome(IBS)is an extremely common chronic intestinal disorder character⁃ized by recurrent abdominal pain and altered bowel habits,significantly impacting patients'quality of life.The etiology of IBS remains incompletely understood.Research has identified low⁃grade intestinal inflammation and immune activation,primarily manifested as an imbalance between pro⁃inflammatory and anti⁃inflammatory cyto⁃kines,as key pathogenic mechanisms in IBS.Among these,interleukin⁃6(IL⁃6),a core pro⁃inflammatory cy⁃tokine,is significantly elevated in IBS patients.IL⁃6 contributes to the pathogenesis of IBS through various mechanisms,including altering individual susceptibility to IBS,promoting gastrointestinal motility and secre⁃tion,activating the hypothalamic⁃pituitary⁃adrenal axis,inducing visceral hypersensitivity,and impairing intes⁃tinal mucosal barrier function.Furthermore,IL⁃6 levels are closely associated with the severity of IBS symptoms.This review summarizes the role and mechanisms of IL⁃6 in IBS,aiming to provide insights and ref⁃erences for clinicians and researchers investigating the etiology of IBS.

关 键 词：肠易激综合征 肠道低度炎症 促炎细胞因子 白细胞介素-6 

分 类 号：R574[医药卫生—消化系统] R363.1[医药卫生—内科学]