舒更葡糖钠对全肺切除患者术后转归的疗效观察  

Effect of sugammadex on postoperative outcomes of patients undergoing pneumonectomy

作　　者：刘涛[1] 王宇轩 孙毅成 高广阔[1] 王春[1] 陈玢[1] 刘伟[1] Liu Tao;Wang Yuxuan;Sun Yicheng;Gao Guangkuo;Wang Chun;Chen Bin;Liu Wei(Department of Anesthesiology,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院麻醉科,101149 [2]首都医科大学附属北京胸科医院胸外科,101149

出　　处：《北京医学》2025年第1期51-54,59,共5页Beijing Medical Journal

摘　　要：目的探讨舒更葡糖钠对全肺切除肺癌患者术后转归的效果。方法选取2019年1月至2024年4月首都医科大学附属北京胸科医院行全肺切除+系统性纵隔淋巴结清扫术的患者93例,其中46例患者术后使用舒更葡糖钠(2 mg/kg)拮抗肌松残余(S组),47例患者术后使用新斯的明(40μg/kg)联合阿托品(10μg/kg)拮抗肌松残余(N组)。收集患者一般资料和临床资料,比较两组术后肺部并发症(postoperative pulmonary complication,PPC)、麻醉后恢复室(post‐anesthesia care unit,PACU)滞留时间、术后住院时间等。结果93例患者中男75例、女18例;年龄40~79岁,平均(62.3±7.6)岁。两组性别、年龄、手术时长、罗库溴铵用量、出血量等的比较,差异无统计学意义(P>0.05)。术后S组PPC发生率与N组的比较,差异无统计学意义(P>0.05);术后S组PACU滞留时间[10(8,12.5)min]比[15(12,19)min]和术后住院时间[11(9,13)min]比[13(10,16)min]小于N组,氧合指数高于N组[357.0(344.3,367.0)mmHg]比[339.0(326.0,371.0)mmHg],差异均有统计学意义(P<0.05)。结论舒更葡糖钠没有降低全肺切除肺癌患者术后PPC发生风险,但可增加患者术后氧合指数,减少PACU的滞留时间和术后住院时间,加快手术室运行效率和患者的康复。Objective To explore the effect of sugammadex on postoperative prognosis of lung cancer patients undergoing pneumonectomy.Methods A total of 93 patients who underwent pneumonectomy and systematic mediastinal lymph node dissection in Beijing Chest Hospital,Capital Medical University from January 2019 to April 2024 were selected.Among them,46 patients were treated with sugammadex(2 mg/kg)to antagonize residual muscle relaxation after surgery(group S),while the remaining 47 patients were treated with neostigmine(40μg/kg)combined with atropine(10μg/kg)to antagonize residual muscle relaxation after surgery(group N).The general and clinical data of patients were collected,and the postoperative pulmonary complications(PPC),postanesthesia care unit(PACU)stay time and postoperative hospitalization time were compared between the two groups.Results Of the 93 patients,75 were males and 18 were females,with a mean age of(62.3±7.6)years.No significant differences were observed between the two groups in gender,age,operative duration,rocuronium dosage,or intraoperative blood loss(P>0.05).There was no significant difference in the incidence of PPC between group S and group N(P>0.05).However,group S demonstrated significantly shorter PACU stay duration[10(8,12.5)min vs.15(12,19)min],shorter postoperative hospital stay[11(9,13)min vs.13(10,16)min],and higher oxygenation index[357.0(344.3,367.0)mmHg vs.339.0(326.0,371.0)mmHg]compared with group N,and the differences were statistically significant(P<0.05).Conclusions Sugammadex does not reduce the risk of PPC in patients with lung cancer after pneumonectomy,but it may increase the postoperative oxygenation index,reduce PACU stay time,and shorten the postoperative hospitalization time,and speed up the operating efficiency of operating room and the recovery of patients.

关 键 词：全肺切除 肌松残余 舒更葡糖钠 新斯的明 

分 类 号：R73[医药卫生—肿瘤]