NAFLD可促进寻常性银屑病的发生:基于双向孟德尔随机化研究  

NAFLD promotes the development of psoriasis vulgaris:a study based on bidirectional Mendelian randomization

作　　者：汪彦平 张惠芳 马小彤 王慧敏 陈兆峰[1,2] WANG Yanping;ZHANG Huifang;MA Xiaotong;WANG Huimin;CHEN Zhaofeng(The First Clinical Medical School,Lanzhou University,Lanzhou 730000,China;Department of Gastroenterology,The First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院消化科,甘肃兰州730000

出　　处：《兰州大学学报(医学版)》2025年第2期60-65,共6页Journal of Lanzhou University(Medical Sciences)

基　　金：甘肃省联合科研基金重大资助项目(No.23JRRA1487)。

摘　　要：目的利用两样本孟德尔随机化(MR)研究方法探讨非酒精性脂肪性肝病与寻常性银屑病之间潜在的双向因果关系。方法从公开发表的全基因组关联分析数据库中获取两样本的单核苷酸多态性(SNP)信息,筛选出合适的SNP作为工具变量。通过使用逆方差加权法、Egger回归法、加权中位数法和加权模型等方法对两样本之间的因果关系进行双向MR分析,并辅以多种敏感性分析校验结果。结果正向MR分析发现,逆方差加权法、加权中位数法均显示非酒精性脂肪性肝病对寻常性银屑病具有显著的因果效应(均P<0.05),而反向MR的结果并不支持反向因果关系。通过MR-pleiotropy函数及MR-PRESSO检验发现均不存在水平多效性(P>0.05),Cochran's Q检验发现不存在异质性(P>0.05),留一法敏感性分析证明了MR研究结果的稳定性。结论MR分析发现非酒精性脂肪性肝病与寻常性银屑病之间存在着正向因果关系。Objective To explore the potential bidirectional causal relationship between non-alcoholic fatty liver disease and psoriasis vulgaris using a two-sample Mendelian randomization(MR)approach.Methods Single nucleotide polymorphism(SNP)information of the two samples was obtained from publicly available genome-wide association analysis databases,and suitable SNPs screened as instrumental variables.The causal relationship between the two samples was analyzed by two-way MR analysis using inverse variance weighting,Egger regression,weighted median and weighted mode,supplemented by various sensitivity analyses to calibrate the results.Results Forward MR analysis revealed that the inverse variance weighting method and the weighted median method showed a significant causal effect of nonalcoholic fatty liver disease on psoriasis vulgaris(both P<0.05),whereas the results of reverse MR did not support reverse causality.The MR-pleiotropy function and MR-PRESSO test revealed no horizontal pleiotropy(P>0.05),Cochran's Q test revealed no heterogeneity(P>0.05),and the leave-one-out sensitivity analysis proved the stability of the MR findings.Conclusion MR analysis revealed a positive causal relationship between non-alcoholic fatty liver disease and psoriasis vulgaris.

关 键 词：非酒精性脂肪性肝病 寻常性银屑病 银屑病 孟德尔随机化分析 因果关系 

分 类 号：R575.5[医药卫生—消化系统] R758.63[医药卫生—内科学]