DNA methylation and genetic regulation in natural populations of East Asian and mixed Eurasian ancestry  

东亚人群和欧亚混合人群的DNA甲基化模式和调控机制

作　　者：Shuangshuang Cheng Zhilin Ning Yan Lu Yuhan Du Xiaonan Yang Minghui Li Dilinuer Maimaitiyiming Shuhua Xu 程爽爽;宁之琳;陆艳;杜宇涵;杨晓楠;李明辉;迪丽努尔·买买提依明;徐书华

机构地区：[1]State Key Laboratory of Genetic Engineering,Human Phenome Institute,Zhangjiang Fudan International Innovation Center,Center for Evolutionary Biology,School of Life Sciences,Department of Liver Surgery and Transplantation Liver Cancer Institute,Zhongshan Hospital,Fudan University,Shanghai 200032,China [2]Key Laboratory of Computational Biology,Shanghai Institute of Nutrition and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China [3]Sinotech Genomics Co.,Ltd.,Shanghai 200120,China [4]The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China [5]Ministry of Education Key Laboratory of Contemporary Anthropology,Fudan University,Shanghai 200438,China [6]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Science Bulletin》2025年第5期638-642,共5页科学通报(英文版)

基　　金：National Key Research and Development Program of China(2023YFC2605400);National Natural Science Foundation of China(32030020,32288101,and 32470649);Shanghai Science and Technology Commission Program(23JS1410100);Office of Global Partnerships(Key Projects Development Fund);The computational work in this study was supported by the CFFF Computing Platform of Fudan University.The funders had no role in the study design,data collection,analysis,decision to publish,or preparation of the manuscript.

摘　　要：References Show full outline Cited by(1)Figures(3)Unlabelled figure Fig.1.Population diversity of DNA methylation Fig.2.Genetic contribution to the population differentiation in DNA methylation…Extras(1)Supplementary Data 1 Elsevier Science Bulletin Volume 70,Issue 5,15 March 2025,Pages 638-642 Science Bulletin Short Communication DNA methylation and genetic regulation in natural populations of East Asian and mixed Eurasian ancestry Author links open overlay panel Shuangshuang Cheng a,Zhilin Ning b,Yan Lu a e,Yuhan Du a,Xiaonan Yang c,Minghui Li c,Dilinuer Maimaitiyiming d,Shuhua Xu a f a State Key Laboratory of Genetic Engineering,Human Phenome Institute,Zhangjiang Fudan International Innovation Center,Center for Evolutionary Biology,School of Life Sciences,Department of Liver Surgery and Transplantation Liver Cancer Institute,Zhongshan Hospital,Fudan University,Shanghai 200032,China b Key Laboratory of Computational Biology,Shanghai Institute of Nutrition and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China c Sinotech Genomics Co.,Ltd.,Shanghai 200120,China d The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China e Ministry of Education Key Laboratory of Contemporary Anthropology,Fudan University,Shanghai 200438,China f School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China Received 27 March 2024,Revised 16 July 2024,Accepted 30 September 2024,Available online 15 October 2024,Version of Record 10 March 2025.What do these dates mean?Show less Add to Mendeley Share Cite https://doi.org/10.1016/j.scib.2024.10.006 Get rights and content Under a Creative Commons license Open access Graphical abstract Download:Download high-res image(109KB)Download:Download full-size image Previous article Next article As an important epigenetic marker,DNA methylation(DNAm)is a stably inherited epigenetic modification that plays an important role in mammalian epigenetics.DNAm is influenced by genetic and environmental factors[1]

关 键 词：SURGERY Eurasian MIXED 

分 类 号：R73[医药卫生—肿瘤]