CAR-NK cell therapy:a potential antiviral platform  

CAR-NK细胞疗法:一种有前景的抗病毒治疗策略

作　　者：Ming-Hao Lin Li-Juan Hu Jeffrey S.Miller Xiao-Jun Huang Xiang-Yu Zhao 林铭浩;胡利娟;Jeffrey S.Miller;黄晓军;赵翔宇

机构地区：[1]Peking University People’s Hospital,Peking University Institute of Hematology,National Clinical Research Center for Hematologic Disease,Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies,Peking University,Beijing 100044,China [2]Department of Medicine,University of Minnesota,Minneapolis,55455,USA [3]Peking-Tsinghua Center for Life Sciences,Beijing 100871,China

出　　处：《Science Bulletin》2025年第5期765-777,共13页科学通报(英文版)

基　　金：National Natural Science Foundation of China(82350105,and 82270228);Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0501200);Science,Technology&Innovation Project of Xiongan New area(2023XACX0004);Beijing Outstanding Young Scientists Project(JWZQ20240101001);Beijing Natural Science Foundation(Z240019),Beijing Nova Program(20220484235).

摘　　要：Viral infections persist as a significant cause of morbidity and mortality worldwide.Conventional therapeutic approaches often fall short in fully eliminating viral infections,primarily due to the emergence of drug resistance.Natural killer(NK)cells,one of the important members of the innate immune system,possess potent immunosurveillance and cytotoxic functions,thereby playing a crucial role in the host’s defense against viral infections.Chimeric antigen receptor(CAR)-NK cell therapy has been developed to redirect the cytotoxic function of NK cells specifically towards virus-infected cells,further enhancing their cytotoxic efficacy.In this manuscript,we review the role of NK cells in antiviral infections and explore the mechanisms by which viruses evade immune detection.Subsequently,we focus on the optimization strategies for CAR-NK cell therapy to address existing limitations.Furthermore,we discuss significant advancements in CAR-NK cell therapy targeting viral infections,including those caused by severe acute respiratory syndrome coronavirus 2,human immunodeficiency virus,hepatitis B virus,human cytomegalovirus,and Epstein-Barr virus.

关 键 词：NK cell therapy VIRUS CAR-NK cell therapy Optimization strategies 

分 类 号：R73[医药卫生—肿瘤]