肺癌循环肿瘤细胞检测新进展  

New advances in the detection of circulating tumor cells in lung cancer

作　　者：张文静 宋紫嫣 李浩 李胜 王振丹 ZHANG Wenjing;SONG Ziyan;LI Hao;LI Sheng;WANG Zhendan

机构地区：[1]山东第一医科大学/山东省医学科学院,济南250117 [2]山东第一医科大学第一附属医院介入科,济南250014 [3]山东第一医科大学附属肿瘤医院肺外科,济南250117

出　　处：《中国医药生物技术》2025年第S1期31-34,66,共5页Chinese Medicinal Biotechnology

基　　金：山东省自然科学基金青年项目(ZR2020QH205)。

摘　　要：肺癌是世界范围内发病率和死亡率最高的恶性肿瘤,其早期诊断困难、预后较差,且目前缺乏有效的早期发现及疗效监测手段。循环肿瘤细胞(CTCs)是指从原发性或转移性癌症病灶脱落进入到外周血液中的肿瘤细胞。CTCs检测作为新型血液生物标志物,可以反映肿瘤完整的生物学信息,具有无创、快速、可重复和可动态监测等优点,在一定程度上弥补了组织活检的不足。CTCs检测技术在肺癌的早期诊断、指导用药、疗效监测和预后评估中扮演着重要的角色。随着相关研究的深入,CTCs检测已从单纯细胞计数发展为基因组、蛋白组等多方位研究。本文对CTCs检测技术及其在肺癌临床应用中的新进展作一综述,旨在为肺癌CTCs检测的临床应用提供参考。Lung cancer is the malignant tumor with the highest incidence and mortality in the world,and its early diagnosis is difficult and the prognosis is poor,and there is a lack of effective early detection and efficacy monitoring methods.Circulating tumor cells(CTCs)refer to tumor cells that are shed from primary or metastatic cancer into the peripheral blood.As a new type of blood biomarker,CTCs detection can reflect the complete biological information of tumors with the advantages of non-invasive,rapid,reproducible and dynamic monitoring,which compensates for the shortcomings of tissue biopsy to a certain extent.CTCs detection technology has played an important role in the early diagnosis,drug guidance,efficacy monitoring and prognosis evaluation of lung cancer.With the deepening of related research,CTCs detection has developed from simple cell counting to genomic,proteomic and other multi-faceted studies.

关 键 词：循环肿瘤细胞 检测 肺癌 诊断 预后 治疗 

分 类 号：R734[医药卫生—肿瘤]