Characteristics and risk differences of different tumor sizes on distant metastases of pancreatic neuroendocrine tumors:A retrospective study in the SEER database  

作　　者：Song-Chen Dong Qi-Yun Tang Lu Wang Fang Fang Dou-Sheng Bai Sheng-Jie Jin Bao-Huan Zhou Guo-Qing Jiang 

机构地区：[1]Department of Hepatobiliary Surgery,Northern Jiangsu People’s Hospital,Yangzhou 225000,China [2]Department of Geriatric Gastroenterology,the First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,China [3]Institute of Neuroendocrine Tumor,Nanjing Medical University,Nanjing 210029,China [4]Center of Endoscopy,Northern Jiangsu People’s Hospital,Yangzhou 225000,China [5]Department of Gastrointestinal Surgery,Northern Jiangsu People’s Hospital,Yangzhou 225000,China [6]Department of Hepatobiliary Surgery,Northern Jiangsu People’s Hospital Affiliated to Yangzhou University,Yangzhou 225000,China

出　　处：《Hepatobiliary & Pancreatic Diseases International》2025年第2期188-196,共9页国际肝胆胰疾病杂志(英文版)

基　　金：supported by a grant from the National Natural Science Foundation of China(82173353)。

摘　　要：Background:The rate of distant metastasis in patients with pancreatic neuroendocrine tumors(PNETs)is20%-50%at the time of initial diagnosis.However,whether tumor size can predict distant metastasis for PNETs remains unknown up to date.Methods:We used Surveillance,Epidemiology,and End Results(SEER)population-based data to collect6089 patients with PNETs from 2010 to 2019.The optimal cut-off point of tumor size to predict distant metastasis was calculated by Youden’s index.Multivariate logistic regression analysis was used to figure out the association between tumor size and distant metastasis patterns.Results:The most common metastatic site was liver(27.2%),followed by bone(3.0%),lung(2.3%)and brain(0.4%).Based on an optimal cut-off value of tumor size(25.5 mm)for predicting distant metastasis determined by Youden’s index,patients were categorized into groups of tumor size<25.5 mm and≥25.5 mm.Multivariate logistic regression analyses showed that,compared with<25.5 mm,tumor size≥25.5 mm was an independent risk predictor of overall distant metastasis[odds ratio(OR)=4.491,95%confidence interval(CI):3.724-5.416,P<0.001]and liver metastasis(OR=4.686,95%CI:3.886-5.651,P<0.001).Conclusions:Tumor size≥25.5 mm was significantly associated with more overall distant and liver metastases.Timely identification of distant metastasis for tumor size≥25.5 mm may provide survival benefit for timely and precise treatment.

关 键 词：Pancreatic neuroendocrine tumors Tumor size Distant metastases 

分 类 号：R735.9[医药卫生—肿瘤]