Effectiveness and safety of the Fuzheng Buxue recipe for myelosuppression induced by platinum-based chemotherapy:a quasi-experimental clinical trial  

作　　者：Min Yang Xiao-Bei Hao Gui-Hua Xu 

机构地区：[1]School of Nursing,Nanjing University of Chinese Medicine,Nanjing 210000,China.

出　　处：《Food and Health》2025年第1期37-43,共7页食品和健康(英文)

基　　金：supported by National Natural Science Foundation of China(82205237);Matching Project for the Youth Fund of the National Natural Science Foundation at Nanjing University of Chinese Medicine(XPT82205237);Jiangsu Provincial Department of Health Medical Science Research Project(Z2021065).

摘　　要：Objective:To assess the effectiveness and safety of the Fuzheng Buxue Dietary Therapy(FBDT)for mitigating myelosuppression caused by chemotherapy containing platinum agents.Methods:In this non-randomized concurrent controlled trial,70 chemotherapy patients were evenly divided into two groups:the FBDT group and a standard care control group.The control group adhered to the standard oncological treatment protocol.Meanwhile,the FBDT group,in addition to the standard regimen,took an additional 300ml of the formula daily with lunch,beginning one week prior to chemotherapy and lasting for two weeks.The study conducted a comprehensive comparative analysis of peripheral blood counts,Traditional Chinese Medicine(TCM)symptom scores,Karnofsky Performance Status(KPS)scores,and the incidence of adverse reactions among patients from both groups.Outcomes:A total of 64 patients completed the study,with 32 in each group.FBDT group exhibited a significantly higher white blood cells recovery level one and three weeks after the chemotherapy compared to control group(3.23±0.68 vs 2.76±0.75(×10^(9)/L);3.92±1.07 vs 3.44±0.91(×10^(9)/L);P<0.05).Furthermore,three weeks after the start of chemotherapy,FBDT group had higher platelet recovery levels than the control group(164.25±54.38 vs 124.81±47.88(×10^(9)/L),P<0.05).Additionally,the TCM syndrome scores in FBDT group were lower(P<0.05),and the KPS scores were significantly higher in FBDT group(P<0.05).No serious adverse events were observed in two groups.Conclusion:FBDT is effective and safe in reducing myelosuppression caused by platinum chemotherapy.Future study should involve larger,multicenter trials to better understand dose-response and overall therapeutic value of FBDT.

关 键 词：MYELOSUPPRESSION chemotherapy TCM dietary therapy peripheral blood counts 

分 类 号：R73[医药卫生—肿瘤]