卡度尼利单抗治疗左肺鳞状细胞癌致免疫相关性肺炎的临床观察及处理  

Clinical observation and management of immune-related pneumonia induced by cadonilimab in the treatment of left lung squamous cell carcinoma

作　　者：杨建 YANG Jian(Department of Clinical Pharmacy,Dafang County People's Hospital,Bijie 551600,China)

机构地区：[1]大方县人民医院临床药学部,贵州毕节551600

出　　处：《中国处方药》2025年第6期95-98,共4页Journal of China Prescription Drug

摘　　要：目的探讨卡度尼利单抗治疗左肺鳞状细胞癌过程中引发免疫相关性肺炎(IRP)的临床表现及处理方法。方法分析1例66岁男性左肺鳞状细胞癌并肺门、右肺、肝及脑转移患者,在接受卡度尼利单抗治疗后出现IRP的临床观察及治疗过程。结果患者在接受卡度尼利单抗治疗第1个疗程后20 d出现咳嗽、咳痰、胸痛、气促及发热等症状,病程超过10 d。经实验室检查和胸部CT诊断符合IRP。患者在接受大剂量甲泼尼龙抑制免疫反应、头孢噻肟钠抗感染及对症支持治疗后,症状逐渐缓解,胸部CT显示IRP完全好转。结论卡度尼利单抗可能引发IRP,早期诊断和及时使用糖皮质激素治疗是关键,同时需警惕合并感染的可能性。Objective To investigate the clinical manifestations and management strategies of immune-related pneumonia(IRP)induced during cadonilimab treatment for left lung squamous cell carcinoma.Methods The clinical observation and treatment process of a 66-year-old male patient with squamous cell carcinoma of the left lung and metastases to the hilum,right lung,liver,and brain were analyzed.The patient developed immune-related pneumonia(IRP)following cadonilimab therapy.Results Showed that 20 days after the first cycle of cadonilimab treatment,the patient presented with symptoms including cough,expectoration,chest pain,dyspnea,and fever,the duration exceeded 10 days.Laboratory tests and chest CT confirmed the diagnosis of IRP.After treatment with high-dose methylprednisolone to suppress the immune response,cefotaxime sodium for anti-infection therapy,and supportive care,the patient’s symptoms gradually improved.Follow-up chest CT demonstrated complete resolution of the IRP.Conclusion Cadonilimab may trigger IRP,and early diagnosis combined with prompt glucocorticoid therapy is critical.Concurrent infections should also be vigilantly monitored.

关 键 词：肺炎 肺疾病 免疫相关性肺炎 人源化免疫球蛋白G1双特异性抗体 免疫 卡度尼利单抗 

分 类 号：R73[医药卫生—肿瘤]