细胞焦亡的分子机制及其在白血病治疗中的研究进展  

The molecular mechanism of pyrodeath and its progress in the treatment of leukemia

作　　者：白晗 黄慧玲 郑钰瑶 蒋艳平 周越菡[1] BAI Han;HUANG Huiling;ZHENG Yuyao(School of Pharmacy,Guilin Medical University,Guilin 541199,China;不详)

机构地区：[1]桂林医学院药学院,广西桂林541199 [2]桂林医学院临桂临床医学院,广西桂林541199

出　　处：《中国处方药》2025年第6期116-120,共5页Journal of China Prescription Drug

基　　金：国家自然科学基金(81660031);桂林医学院自治区级大学生创新创业项目(S202310601087、S202410601097)。

摘　　要：白血病是常见的血液系统恶性肿瘤,我国已将其列入重点防治的十大恶性肿瘤之一。细胞焦亡作为一种独特的程序性细胞死亡方式,主要通过激活Gasdermin蛋白,促进细胞膜孔的形成,诱导白细胞介素-18(IL-18)和白细胞介素-1β(IL-1β)等促炎细胞因子从小孔中释放,最终导致细胞死亡。近年来的研究表明,细胞焦亡可以抑制肿瘤的增殖、侵袭和转移,因此,诱导白血病发生细胞焦亡被认为是一种潜在的癌症治疗策略。本文主要概述了细胞焦亡的分子机制及其在白血病治疗中的潜在作用,为探索预防和治疗白血病的途径提供新思路。Leukemia,a prevalent malignant tumor of the hematopoietic system,is among the top ten malignant tumors prioritized for prevention and treatment in China.Pyroptosis,a distinct form of programmed cell death,is primarily facilitated by the activation of Gasdermin proteins,which promote the formation of cell membrane pores.This process induces the release of pro-inflammatory cytokines such as IL-18 and IL-1βthrough these pores,culminating in cell death.Recent studies have demonstrated that pyroptosis can inhibit tumor proliferation,invasion and metastasis,making the induction of pyroptosis in leukemia a potential therapeutic strategy.This paper summarizes the molecular mechanisms of pyroptosis and its potential role in leukemia treatment,offering new avenues for exploring the prevention and treatment of leukemia.

关 键 词：白血病 细胞焦亡 分子机制 

分 类 号：R73[医药卫生—肿瘤]