中国产妇配偶产后抑郁发生率的Meta分析  

Meta-analysis of the Incidence of Postpartum Depression among Maternal Spouses in China

作　　者：樊宇 李蓉[2] 龚双英 杨小娟 李蕊 FAN Yu;LI Rong;GONG Shuangying;YANG Xiaojuan;LI Rui(School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China;Department of Obstetric,Sichuan Academy of Medical Sciences·Sichuan Provincial People's Hospital,Chengdu 610072,China;Department of Burns,Sichuan Academy of Medical Sciences·Sichuan Provincial People's Hospital,Chengdu 610072,China)

机构地区：[1]电子科技大学医学院,四川省成都市610054 [2]四川省医学科学院·四川省人民医院产科,四川省成都市610072 [3]四川省医学科学院·四川省人民医院烧伤科,四川省成都市610072

出　　处：《中国全科医学》2025年第17期2179-2185,共7页Chinese General Practice

基　　金：四川省科技计划项目(2020YFS0400)。

摘　　要：背景产后抑郁不仅可能发生于产妇,还可能发生于产妇配偶,这不仅影响其生活质量、加重社会和家庭经济负担,也不利于儿童生长发育,及早识别其发生的影响因素具有重要意义。目的通过Meta分析明确中国产妇配偶产后抑郁的发生率。方法计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库、PubMed、Web of Science、CINAHL、Embase、Cochrane Library数据库中有关中国产妇配偶产后抑郁发生率的队列研究、病例对照研究和横断面研究,检索时间为建库至2024-03-19。由2名研究者独立筛选文献,对纳入研究进行数据提取、文献质量评估,采用Stata 14.0软件进行Meta分析。结果最终纳入39篇文献,总样本量12162例。Meta分析结果显示,我国产妇配偶产后抑郁发生率为14%(95%CI=12%~17%)。亚组分析结果显示,产后1个月内配偶产后抑郁发生率为17%(95%CI=13%~22%),产后1个月~1年内为13%(95%CI=10%~15%);内陆地区为17%(95%CI=11%~23%),沿海地区为13%(95%CI=11%~16%);测量工具为EPDS的研究中配偶产后抑郁发生率为13%(95%CI=11%~16%),其他研究工具为18%(95%CI=10%~29%);初产妇配偶产后抑郁发生率为15%(95%CI=11%~21%),经产妇配偶为14%(95%CI=11%~18%);发表年份2007—2016年为16%(95%CI=10%~22%),2017—2023年为14%(95%CI=12%~16%)。通过逐一剔除文献的方法进行敏感性分析,合并效应量未发生明显改变,提示Meta合并结果较为稳健。漏斗图两侧各研究点分布基本对称,Egger's检验结果显示t=1.79,P=0.082,提示不存在明显的发表偏倚。结论中国产妇配偶产后抑郁发生率较高,总发生率为14%,其中产后1个月内发生率高至17%,应重视早期筛查及防治工作。Background Postpartum depression may occur not only in the mother but also in spouses,which affects their quality of life,increases the social and family economic burden,and is not conducive to the growth and development of the child.Therefore,it is important to identify the factors that influence its occurrence at an early stage.Objective To clarify the incidence of postpartum depression in Chinese maternal spouses through meta-analysis.Methods A computerized search was performed for cohort studies,case-control studies,and cross-sectional studies on the incidence of postpartum depression in Chinese maternal spouses in the databases of CNKI,Wanfang Data,VIP,CBM,PubMed,Web of Science,CINAHL,Embase,and Cochrane Library,with the time of search being from the establishment of the databases to March 2024.The search was conducted from the time of database construction to 2024-03-19.Two researchers independently screened the literature,and the included studies were subjected to data extraction,literature quality assessment,and meta-analysis by Stata 14.0 software.Results 39 papers were finally included,with a total sample size of 12162 cases.Meta-analysis results showed that the prevalence of postpartum depression among maternal spouses in China was 14%(95%CI=12%-17%).The results of subgroup analysis showed that the incidence of postpartum depression in spouses was 17%(95%CI=13%-22%)within 1 month postpartum and 13%(95%CI=10%-15%)within 1 month-1 year postpartum;the incidence was 17%(95%CI=11%-23%)in inland areas and 13%(95%CI=11%-16%)in coastal regions;the measurement tool EPDS showed an incidence of 13%(95%CI=11%-16%)for spouses in studies using the EPDS and 18%(95%CI=10%-29%)for other study instruments;the incidence of postpartum depression was 15%(95%CI=11%-21%)for spouses of primiparous women and 14%(95%CI=11%-18%)for spouses of multiparous mothers.For the year of publication,the incidence was 16%(95%CI=10%-22%)for studies published from 2007 to 2016 and 14%(95%CI=12%-16%)for studies published from 2017 to 2023.Sen

关 键 词：产后 抑郁 配偶 中国 发生率 META分析 

分 类 号：R749.42[医药卫生—神经病学与精神病学]