热敏灸结合益气养阴法治疗对急性髓系白血病气阴两虚证的临床疗效与安全性观察  

Clinical efficacy and safety observation of heat-sensitive moxibustion combined with Qi-yin nourishing therapy for acute myeloid leukemia syndrome of Qi-yin deficiency

作　　者：张明明 孙静[1] 王羽 李三科 陶贞 曹富娇 马晔 Zhang Mingming;Sun Jing;Wang Yu;Li Sanke;Tao Zhen;Cao Fujiao;Ma Ye(Department of Blood Ward,Zhengzhou Third People's Hospital,Zhengzhou 450000,Henan,China)

机构地区：[1]郑州市第三人民医院血液一病区,河南郑州450000

出　　处：《贵州医药》2025年第4期526-529,共4页Guizhou Medical Journal

基　　金：河南省医学科技攻关计划项目(LHGJ20200723)。

摘　　要：目的探讨热敏灸结合益气养阴法治疗对急性髓系白血病(AML)气阴两虚证的临床疗效与安全性。方法选取本院收治的60例急性髓系白血病气阴两虚证患者,按照入院顺序随机分为试验组和对照组,各30例。两组均接受常规化疗,试验组在对照组的基础上给予热敏灸结合益气养阴法治疗。比较两组患者的疗效;治疗前后中医证候积分、T淋巴细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平、血象指标[全血血小板计数(PLT)、血红蛋白(Hb)、全血白细胞计数(WBC)]水平、骨髓象(骨髓原幼细胞比例)情况;不良反应发生情况。结果试验组的治疗总有效率高于对照组(P<0.05)。治疗后,两组患者的中医证候积分均下降,且试验组低于对照组(P<0.05);对照组患者的CD3^(+)、CD4^(+)、CD8^(+)水平均低于治疗前(P<0.05);试验组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于治疗前,CD8^(+)水平低于治疗前(P<0.05);试验组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)水平低于对照组(P<0.05);两组患者的Hb、PLT、WBC水平均低于治疗前,试验组的Hb、PLT水平高于对照组,WBC水平低于对照组(P<0.05);两组患者的骨髓原幼细胞比例均低于治疗前,试验组骨髓原幼细胞比例低于对照组(P<0.05)。两组的不良反应发生率差异无统计学意义(P>0.05)。结论热敏灸结合益气养阴法治疗AML气阴两虚证疗效显著,可减轻AML患者的症状,不仅可提升患者的免疫功能,还能够改善患者的造血功能,有效抑制AML细胞增殖,安全性良好。Objective To investigate the clinical efficacy and safety of heat-sensitive moxibustion combined with Qi-yin nourishing for acute myeloid leukemia(AML).Methods 60 patients with Qi-yin deficiency syndrome of acute myeloid leukemia admitted to our hospital from March 2020 to March 2024 were randomly divided into test group and control group according to admission order,with 30 patients in each group.The two groups were treated with conventional chemotherapy and nursing,and the experimental group was treated with heat-sensitive moxibustion combined with invigorating qi and nourishing Yin.The efficacy of the two groups was compared.Compared with the two groups of TCM syndrome scores,T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))levels,blood indicators that hemoglobin(Hb),whole blood white blood cell count(WBC),whole blood platelet count(PLT)levels,and bone marrow images(proportion of bone marrow protoliocytes)before and after treatment.Compared with the two groups in the occurrence of adverse reactions.Results In a study comparing an experimental group with a control group,the experimental group showed a significantly higher effective rate of 76.67%compared to 50.00%in the control group(P<0.05).Post-treatment,TCM syndrome scores decreased in both groups,with the experimental group scoring lower than the control.The experimental group also showed increased levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+),while CD8^(+)levels decreased(P<0.05).In contrast,all these levels decreased in the control group post-treatment.The experimental group also had higher hemoglobin(Hb)and platelet(PLT)levels,but lower white blood cell(WBC)counts compared to the control group after treatment(P<0.05).Bone marrow proplastic cells were lower in both groups after treatment,but the experimental group had a significantly higher proportion than the control group(P<0.05).Adverse reaction rates were 10.00%in the experimental group and 26.67%in the control group,and there were no statistically significant differences between the two(P

关 键 词：热敏灸 益气养阴 急性髓系白血病 气阴两虚证 临床疗效 安全性 

分 类 号：R733.71[医药卫生—肿瘤]