肝脏力医学  

Liver mechanomedicine

作　　者：刘昌[1] 曲凯 周夏青 贾渊博 程波 徐峰[3] Liu Chang;Qu Kai;Zhou Xiaqing;Jia Yuanbo;Cheng Bo;Xu Feng(Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation,The Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710004,China;Key Laboratory of Surgical Critical Care and Life Support,Ministry of Education,Xi′an 710049,China;Bioinspired Engineering and Biomechanics Center,Xi′an Jiaotong University,Xi′an 710049,China)

机构地区：[1]西安交通大学第二附属医院肝胆胰与肝移植外科,西安710004 [2]外科重症及生命支持教育部重点实验室,西安710049 [3]西安交通大学仿生工程与生物力学研究所,西安710049

出　　处：《中华消化外科杂志》2025年第2期161-172,共12页Chinese Journal of Digestive Surgery

基　　金：国家杰出青年科学基金(12225208)。

摘　　要：肝硬化和肝癌等肝疾病长期对人类健康构成严重威胁,其诊断与治疗是医学研究重要课题。传统的诊断与治疗方法主要围绕肝疾病的生物化学特性展开,缺乏对于分子、细胞与组织尺度下力学微环境的考量,导致难以满足临床需求。随着生物力学和力生物学在肝疾病研究中逐步发展,利用肝脏力学特性研究相关疾病,不仅在基础研究方面展现出深远影响力,而且在肝疾病临床诊断与治疗中显现出巨大潜力。但是,基础研究与临床治疗上对肝脏力学特性尚缺乏深入探讨,具体作用机制与应用场景并不明晰。笔者提出并系统介绍肝脏力医学这一新兴概念,讨论肝脏生物力学特性及其在肝疾病发展过程中的变化与影响,阐明细胞层面力学响应与信号转导的生物学机制,探讨肝疾病诊断与治疗手段中力学特征的应用,旨在为基础研究与临床实践提供新视角。Liver diseases,particularly cirrhosis and cancer,significantly threat human health for a long time,and their diagnosis and treatment are important topics in medical research.Traditional diagnostic and therapeutic approaches have focused on biochemical properties of liver diseases,yet often neglecting the mechanical microenvironment of liver at molecular,cellular,and tissue levels.This oversight makes it difficult to meet clinical needs.Recent advancements in biomechanics and mechanobiology have underscored the importance of mechanical properties of liver in understanding disease mechanisms,presenting profound implications for both basic research and clinical practice.However,there is still a lack of in-depth exploration of the mechanical properties of liver in both basic research and clinical treatment,making it unclear of the specific mechanisms and application scenarios.The authors propose and introduce the emerging field of liver mechanomedicine,examine the biomechanical properties of liver and their alterations during disease progression,elucidate mechanobiological mechanisms of cellular mechanical responses and signal transduction,explore the application of mechanical characteristics in the diagnosis and treatment of liver diseases,aiming to provide a new perspective for basic research and clinical practice.

关 键 词：肝疾病 肝脏生物力学 肝脏力生物学 肝脏力诊断学 肝脏力治疗学 

分 类 号：R73[医药卫生—肿瘤]