钇‑90微球选择性内放射治疗在结直肠癌肝转移中的应用进展  

Application progress of yttrium‑90 selective internal radiation therapy in colorectal liver metastases

作　　者：吴广斌 许晓磊 何淼龙 黄鑫[4] 张琳[4] 廖勇 冯晓彬[4] Wu Guangbin;Xu Xiaolei;He Miaolong;Huang Xin;Zhang Lin;Liao Yong;Feng Xiaobin(Clinical Medical School,Qinghai University,Xining 810001,China;Department of Hepatopancreatobiliary Surgery,Qinghai Research Key Laboratory for Echinococcosis,Qinghai University Affiliated Hospital,Xining 810001,China;Department of Hepatopancreatobiliary Surgery,Beijing Tsinghua Changgung Hospital,Tsinghua University,Beijing 102218,China;Department of Hepatopancreatobiliary Surgery,Yttrium‑90 Precision Interventional Radiotherapy Center for Liver Cancer,Beijing Tsinghua Changgung Hospital,Tsinghua University,Beijing 102218,China)

机构地区：[1]青海大学临床医学院,西宁810001 [2]青海大学附属医院肝胆胰外科青海省包虫病研究重点实验室,西宁810001 [3]清华大学附属北京清华长庚医院肝胆胰外科,北京102218 [4]清华大学附属北京清华长庚医院肝胆胰外科钇‑90肝癌精准介入放射治疗中心,北京102218

出　　处：《中华消化外科杂志》2025年第2期266-270,共5页Chinese Journal of Digestive Surgery

基　　金：青海省昆仑英才‑中青年人才托举项目(2022QHSKXRCTJ17);青海大学附属医院中青年基金(ASRF‑2021‑YB‑17);清华大学精准医学研究项目(2022ZLA005)。

摘　　要：近年来,结直肠癌继发性肝转移的发病率持续上升,对人类生命健康构成巨大威胁。尽管手术与化疗等传统治疗方法取得一定疗效,但对于手术难以切除或化疗耐药、难治性患者,治疗选择仍相当有限。钇‑90微球选择性内放射治疗作为一种创新的局部治疗手段,相关临床研究已证明其在结直肠癌肝转移患者治疗中的有效性和安全性。笔者综述钇‑90微球选择性内放射治疗在结直肠癌肝转移治疗领域的研究背景、作用机制与原理,并深入探讨其在临床实践中的应用进展,旨在为临床医师提供参考,以期提升结直肠癌肝转移患者疗效和生命质量。In recent years,the incidence of liver metastasis from colorectal cancer has continued to rise,posing a significant threat to human health and life.Although traditional treatments such as surgery and chemotherapy have shown some efficacy in certain patients,options remain limited for those who are not surgical candidates or are resistant to chemotherapy.Yttrium‐90 microsphere selective internal radiation therapy,as an innovative local treatment,has fully demonstrated its effectiveness and safety in treating colorectal cancer liver metastasis patients.The authors review the research background,mechanisms,and principles of yttrium‐90 microsphere selective internal radiation therapy in the field of colorectal cancer liver metastasis,and to explore its application progress in clinical practice,aiming to provide clinical doctors with more comprehensive and detailed reference information,with the goal of improving treatment outcomes and quality of life for colorectal cancer liver metastasis patients.

关 键 词：结肠肿瘤 直肠肿瘤 肝转移 钇‑90微球 选择性内放射治疗 

分 类 号：R73[医药卫生—肿瘤]