52例肺浸润性腺癌的临床病理特征及肺门纵隔淋巴结转移风险因素分析  

Clinical and pathological characteristics of 52 cases of pulmonary invasive adenocarcinoma and analysis of risk factors for hilar and mediastinal lymph node metastasis

作　　者：王道笃 赵其炯 周志标 陈鑫 WANG Dao-du;ZHAO Qi-jiong;ZHOU Zhi-biao;CHEN Xin(Department of Surgical Oncology,the Second People′s Hospital of Shanwei,Shanwei,Guangdong 516600,China)

机构地区：[1]汕尾逸挥基金医院肿瘤外科,广东汕尾516600

出　　处：《岭南现代临床外科》2025年第1期36-40,共5页Lingnan Modern Clinics in Surgery

摘　　要：目的回顾性分析非小细胞肺腺癌的临床病理特征及肺门纵隔淋巴结转移风险因素。方法回顾性分析汕尾逸挥基金医院肿瘤外科2018年9月至2024年9月期间初次手术且术后病理报告为浸润性腺癌的患者52例,通过卡方分析及Logistic回归模型分析淋巴结转移的风险因素。结果临床病理特征中,男女比例为0.92:1,发生淋巴结转移6人(11.5%)。单因素分析显示原发病灶肿瘤直径≥2 cm,CEA≥5 ng/mL,发生肺门纵隔淋巴结转移的风险增高(P<0.05)。多因素logistic分析显示,肿瘤最大直径≥2 cm是淋巴结转移的风险因素,具有统计学意义(P<0.05)。结论肺浸润性腺癌患者中,肿块>2 cm及血CEA≥5 ng/mL是淋巴结转移的危险因素。Objective This study aims to retrospectively analyze the clinicopathological characteristics and risk factors for hilar and mediastinal lymph node metastasis in non⁃small cell lung adenocarcinoma.Methods We conducted a retrospective analysis of 52 patients with invasive adenocarcinoma who underwent initial surgery and had postoperative pathology reports from October 2018 to October 2023 at the Oncological Surgery Department of Shanwei Second People′s Hospital.We investigated the risk factors for hilar mediastinal lymph node metastasis,and used chi⁃square tests and logistic regression models to find the threshold points of risk factors through the ROC curve.Results Regarding clinicopathological characteristics,the male⁃to⁃female ratio was 0.92∶1,with 6 patients(11.5%)developing lymph node metastasis.Univariate analysis revealed that a primary tumor diameter≥2 cm and CEA≥5 ng/mL increased the risk of hilar and mediastinal lymph node metastasis(P<0.05).Multivariate logistic analysis demonstrated that a tumor maximum diameter of≥2 cm was a statistically significant risk factor for lymph node metastasis(P<0.05).Conclusion In patients with invasine adenocarcinoma of the lung,a tumor mass larger than 2 cm and aserum CEA level of 5 ng/mL are risk factors for lymph node metastasis.

关 键 词：非小细胞肺癌 肿瘤最大直径 癌胚抗原 淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]