肠道微生物与第一秒用力呼气容积的两样本孟德尔随机化研究及其中医药应用思考  

Two-sample Mendelian Randomization Study of Gut Microbiota and FEV1 and the Thpughts of Its Application in the TCM Field

作　　者：黄徐睿 李潇宁 HUANG Xurui;LI Xiaoning(Heyi Community Health Service Center,Fengtai District,Beijing 100071,China;The Third Affiliated Hospital to Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京市丰台区和义社区卫生服务中心,北京100071 [2]北京中医药大学第三附属医院,北京100029

出　　处：《中国中医药图书情报杂志》2025年第2期153-160,共8页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

摘　　要：目的 利用两样本孟德尔随机化方法探究肠道微生物与第一秒用力呼气容积(FEV1)的因果关系,并探讨其在中医药领域的应用。方法 采用MiBioGen数据库中的肠道微生物GWAS数据和IEU OpenGWAS发布的FEV1相关GWAS数据,根据预设阈值提取工具变量。主要采用逆方差加权法进行分析,通过留一法、异质性检验、水平基因多效性检验、MR-Egger回归截距分析等方法验证结果的稳定性和可靠性。结果 通过逆方差加权法共确定6种肠道微生物和FEV1之间的因果关系。结论 肠道微生物在FEV1的变化中可能发挥一定作用,该结果一定程度上验证了中医“肺与大肠相表里”理论。Objective To explore the causal relationship between gut microbiota and forced expiratory volume in the first second(FEV1)using two-sample Mendelian randomization method.To explore its application in the TCM field.Methods The GWAS data of gut microbiota from the MiBioGen consortium study and the GWAS data of FEV1 published by IEU OpenGWAS in the public database,and instrumental variables were extracted according to prespecified thresholds.inverse-varianceweighted(IVW)method was used to analyze the results.The stability and reliability of the results were verified by leave-one-out method,heterogeneity test,horizontal gene pleiotropy test,MR-Egger regression intercept analysis and other methods.Results A total of six gut microbes were identified as causal associations between FEV1 by IVW method.Conclusion The gut microbiota may play a role in the change of FEV1,which confirms the TCM theory that“the lung and large intestine are externally and internally correlated”to a certain extent.

关 键 词：孟德尔随机化 肠道微生物 第一秒用力呼气容积 因果关系 

分 类 号：R222.19[医药卫生—中医基础理论]