铁死亡机制和骨肉瘤进展  

Research progress on ferroptosis mechanism and osteosarcoma

作　　者：梁涛 刘卓超[1] 张伟滨[1] LIANG Tao;LIU Zhuochao;ZHANG Weibin(Department of Orthopedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院骨科,上海200025

出　　处：《外科研究与新技术(中英文)》2025年第1期1-8,F0002,共9页Surgical Research and New Technique

基　　金：国家自然科学基金(8247110964,8220100739,82141116)。

摘　　要：骨肉瘤是儿童和青少年最常见的原发性骨肿瘤,恶性程度高,预后较差。目前治疗模式依旧是以新辅助化疗-手术-辅助化疗的综合治疗为主,但近40年来,化疗所带来的生存获益并没有显著提升。铁死亡作为新发现的细胞死亡形式,过去10年间研究进展迅速,不断有治疗肿瘤的靶点被发掘。因而,本文从铁死亡的提出、发展节点和机制出发,进一步讨论了骨肉瘤领域铁死亡的研究成果,展望了其发展前景,并提出了其亟待解决的问题。Osteosarcoma is the most common primary bone tumor in children and adolescents,with a high degree of malignancy and a poor prognosis.The prevailing treatment paradigm continues to be based on a multimodality therapy of neoadjuvant chemotherapy-surgery-adjuvant chemotherapy,but the survival benefit provided by chemotherapy has remained relatively constant over the past 40 years.Ferroptosis,as a newly discovered form of cell death,has seen rapid research progress over the past decade,and targets for tumor treatment are constantly discovered.Thus,this article commenced with the proposal,developmental nodes,and underlying mechanisms of ferroptosis,then summarized the research results on ferroptosis in osteosarcoma,anticipated its developmental prospects,and highlighted the most urgent things in this field.

关 键 词：铁死亡 骨肉瘤 细胞死亡 肿瘤诱导 综合治疗 

分 类 号：R738.1[医药卫生—肿瘤]