Gut Microbiota and Vascular Diseases: An Update  

作　　者：Jiaqi Wu Yuxuan Li Peipei Yang Jiantao Fu Yidong Wang 

机构地区：[1]Department of Gastroenterology,The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China [2]Translational Medicine Center,The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China [3]Clinical Center for HIV/AIDS,Beijing Ditan Hospital,Capital Medical University,Beijing,100015,China [4]Department of Cardiology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310009,China

出　　处：《Cardiovascular Innovations and Applications》2024年第1期128-138,共11页心血管创新与应用(英文)

基　　金：supported by the National Natural Science Foundation of China(grant no.82100500).

摘　　要：Vascular diseases,including atherosclerosis,aneurysms,and vascular calcification,are a leading cause of morbidity and mortality worldwide.In past decades,the gut microbiota has been found to be an indispensable population exert-ing effects on hosts under physiological and pathological conditions.Gut microbiota-derived metabolites,such as trimethylamine-N-oxide and short-chain fatty acids,mediate these effects by regulating vascular cells systematically.Translation of research knowledge to clinical scenarios has led to the development of new therapies including dietary interventions and metabolite inhibitors.This review describes recent advancements in understanding of the interplay between the gut microbiota and vascular dysfunction,and potential treatments for vascular diseases.

关 键 词：Gut microbiota ATHEROSCLEROSIS ANEURYSMS vascular calcification THERAPY 

分 类 号：R54[医药卫生—心血管疾病]