IL-6 and D-dimer Levels at Admission Predict Cardiac Injury and Early Mortality during SARS-CoV-2 Infection  

作　　者：Kexin Peng Beibei Du Daoyuan Si Lina Jin Bo Yang Neil Johnson Lujia Ni Qian Zhang Mohammed Ali Azam Patrick FHLai Slava Epelman Kumaraswamy Nanthakumar Ping Yang 

机构地区：[1]Department of Cardiology,China-Japan Union Hospital of Jilin University,Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease,Changchun,China [2]Department of Epidemiology and Biostatistics,School of Public Health,Jilin University,Changchun,China [3]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [4]Department of Ultrasound,China-Japan Hospital of Jilin University,Changchun,China [5]The Hull Family Cardiac Fibrillation Management Laboratory,Toronto General Hospital,University Health Network,Toronto,Canada [6]Peter Munk Cardiac Centre,University Health Network,Toronto,Canada [7]The Ted Rogers Centre for Heart Research,Toronto,Canada

出　　处：《Cardiovascular Innovations and Applications》2024年第1期311-322,共12页心血管创新与应用(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(No.82100337);the General Project of Natural Science Foundation of Jilin Province(No.YDZJ202201ZYTS097);the Bethune Program of Jilin University(No.419161900105).

摘　　要：Background:We previously described the mortality associated with cardiac injury in patients with coronavirus dis-ease 2019(COVID-19).The activation of immune and thrombotic biomarkers at admission,and their ability to predict cardiac injury and mortality patterns in COVID-19,remains unclear.Methods:This retrospective cohort study included 170 patients with COVID-19 with cardiac injury at the time of admis-sion to Tongji Hospital in Wuhan between January 29,2020,and March 8,2020.The temporal evolution of inflammatory cytokines,coagulation markers,clinical treatment,and mortality were analyzed.Continuous variables are expressed as median(interquartile range).The Mann-Whitney test was used for two-group comparisons,whereas the Kruskal-Wallis test was used for comparisons among three groups.Categorical variables are expressed as proportions and percentages,and Fisher’s exact test was used to compare differences.Amultivariate regression model was used to predict in-hospital death.A simple linear regression analysis was applied to examine the correlation between baseline biomarkers and peak cTnI levels.Results:Of the 170 patients,60(35.3%)died early(<21 d),and 61(35.9%)died after a prolonged stay.The admis-sion laboratory findings correlating with early death were elevated interleukin 6(IL-6)(P<0.0001),tumor necrosis factor-α(P=0.0025),and C-reactive protein(P<0.0001).We observed the trajectory of biomarker changes in patients after admission hospitalization,and determined that early mortality was associated with a rapidly increasing D-dimer level,and gradually decreasing platelet and lymphocyte counts.Multivariate and simple linear regression models indi-cated that the risk of death was associated with immune and thrombotic pathway activation.Elevated admission cTnI levels were associated with elevated IL-6(P=0.03)and D-dimer(P=0.0021)levels.Conclusion:In patients with COVID-19 with cardiac injury,IL-6 and D-dimer levels at admission predicted sub-sequently elevated cTnI levels and early death,thus highlighting the

关 键 词：COVID-19 cardiac injury inflammation immune activation thrombotic activation ANTICOAGULATION 

分 类 号：R563.1[医药卫生—呼吸系统]