淀粉水凝胶药物缓释系统:制备、性能调控与应用  

Starch Hydrogel Drug Slow-Release System:Preparation,Property Regulation and Application

作　　者：唐亮东 林铭濠 封余贤 黄科林 郭映桃 苏艳蕾 蓝平 张学选 Tang Liangdong;Lin Minghao;Feng Yuxian;Huang Kelin;Guo Yingtao;Su Yanlei;Lan Ping;Zhang Xuexuan(Guangxi Institute of Industrial Technology,Nanning 530022;Institute of New Functional Materials,Guangxi Institute of Industrial Technology,Nanning 530022;School of Chemistry and Chemical Engineering,Guangxi Minzu University,Guangxi Key Laboratory for Polysaccharide Materials and Modification,Nanning 530007)

机构地区：[1]广西产业技术研究院,南宁530022 [2]广西产研院新型功能材料研究所有限公司,南宁530022 [3]广西民族大学化学化工学院广西多糖材料与改性重点实验室,南宁530007

出　　处：《中国粮油学报》2025年第3期228-234,共7页Journal of the Chinese Cereals and Oils Association

基　　金：广西生物多糖分离纯化及改性研究平台建设项目(桂科ZY18076005);广西产研院新型功能材料研究所有限公司技术开发合作项目(200309);广西大学生创新创业训练计划项目(S202210608133、S202310608144);广西本科高校示范性现代产业学院(广西民族大学现代产业学院)项目(20220929)。

摘　　要：淀粉水凝胶作为一种可降解、生物相容性良好的材料,已经被广泛应用于药物缓释领域。本文综述了不同的淀粉水凝胶制备方法,分析了不同制备方法的优缺点。列举了淀粉水凝胶药物缓释系统的主要性能指标,以及水凝胶合成过程和药物释放过程中不同参数对这些性能的影响,对淀粉基水凝胶在多个应用领域的相关研究进行综述,并探讨目前研究中面临的挑战。Starch hydrogels,as a degradable material with excellent biocompatibility,have been widely utilized in the field of drug delivery.In this article,various methods for preparing starch hydrogels were reviewed,and the advantages and disadvantages of different preparation methods were analyzed.The major performance indicators of starch hydrogel drug delivery systems were outlined,along with an examination of the impact of various parameters during hydrogel synthesis and drug release processes on these performances.A comprehensive review of relevant research on starch-based hydrogels in various application areas was presented,along with a discussion of the challenges currently faced in research.

关 键 词：淀粉 水凝胶 药物缓释 制备方法 性能指标 

分 类 号：Q539.1[生物学—生物化学]