Uncovering the Genetic Link between Acute Myocardial Infarction and Ulcerative Colitis Co-Morbidity through a Systems Biology Approach  

作　　者：Chen Chang Ruping Cai Qiang Wu Qiang Su 

机构地区：[1]Department of Cardiology,Affiliated Hospital of Guilin Medical University,Guilin 541000,China [2]Department of Rehabilitation Medicine,The Third Affiliated Hospital of Guangxi Medical University,Nanning 530000,China [3]Department of Cardiology,the Sixth Medical Centre,Chinese PLA General Hospital,Beijing 100048,China [4]Journal of Geriatric Cardiology Editorial Office,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《Cardiovascular Innovations and Applications》2023年第1期244-263,共20页心血管创新与应用(英文)

基　　金：This work was supported by the Guangxi Natural Science Foundation(2020GXNSFDA238007);the Key Research and Development Program of Guangxi(AB20159005).

摘　　要：Background:Cardiovascular diseases,particularly acute myocardial infarction,are the leading cause of disability and death.Atherosclerosis,the pathological basis of AMI,can be accelerated by chronic inflammation.Ulcerative colitis(UC),a chronic inflammatory disease associated with immunity,contributes to the risk of AMI development.However,controversy continues to surround the relationship between these two diseases.The present study unravels the pathogenesis of AMI and UC,to provide a new perspective on the clinical management of patients with these co-morbidities.Methods:Microarray datasets GSE66360 and GSE87473 were downloaded from the Gene Expression Omnibus database.Common differentially expressed genes(co-DEGs)between AMI and UC were identified,and the following analyses were performed:enrichment analysis,protein-protein interaction network construction,hub gene identifica-tion and co-expression analysis.Results:A total of 267 co-DEGs(233 upregulated and 34 downregulated)were screened for further analysis.GO enrichment analysis suggested important roles of chemokines and cytokines in AMI and UC.In addition,thelipopolysaccharide-mediated signaling pathway was found to be closely associated with both diseases.KEGG enrich-ment analysis revealed that lipid and atherosclerosis,NF-κB,TNF and IL-17 signaling pathways are the core mecha-nisms involved in the progression of both diseases.Finally,11 hub genes were identified with cytoHubba:TNF,IL1B,TLR2,CXCL8,STAT3,MMP9,ITGAX,CCL4,CSF1R,ICAM1 and CXCL1.Conclusion:This study reveals a co-pathogenesis mechanism of AMI and UC regulated by specific hub genes,thus providing ideas for further mechanistic studies,and new perspectives on the clinical management of patients with these comorbidities.

关 键 词：acute myocardial infarction ulcerative colitis BIOINFORMATICS differentially expressed genes hub genes 

分 类 号：R541.4[医药卫生—心血管疾病]