神经炎性标志物在颅脑创伤诊治中的应用进展  

Advances in neuroinflammatory markers in the diagnosis and management of traumatic brain injury

作　　者：李欣梦 刘紫薇 刘卫钰 吴佳诺 邓宇航 黄贤键[1] Li Xinmeng;Liu Ziwei;Liu Weiyu;Wu Jianuo;Deng Yuhang;Huang Xianjian(Department of Neurosurgery,Shenzhen Second People's Hospital&The First Affiliated Hospital of Shenzhen University,Shenzhen 518000,China)

机构地区：[1]深圳市第二人民医院,深圳大学第一附属医院神经外科,518000

出　　处：《神经疾病与精神卫生》2025年第3期177-183,共7页Journal of Neuroscience and Mental Health

基　　金：广东省自然科学基金(2023A1515010320)。

摘　　要：颅脑创伤发生后数分钟内,受伤的大脑会发生强烈的炎症反应。创伤后炎症反应包括释放促炎细胞因子和抗炎细胞因子、神经营养因子的调节、细胞迁移、吞噬等。神经炎症过程既参与继发性脑损伤的发生,也发挥促进神经修复作用。各类细胞因子参与颅脑创伤后炎症反应过程,与创伤严重程度和预后有较明显相关性。本综述对颅脑创伤后各类炎症因子的机制和表达情况以及其作为颅脑创伤后标志物对预后的判断及诊治作用进行分析,以期为炎症靶向治疗提供合适细胞因子靶点,改善颅脑创伤患者预后。Within minutes following a traumatic brain injury,a pronounced inflammatory response occurs in the affected brain.The post-traumatic inflammatory response encompasses the release of proinflammatory and anti-inflammatory cytokines,regulation of neurotrophic factors,cellular migration,and phagocytosis.The neuroinflammatory process is implicated in the occurrence of secondary brain injury while also facilitating neurorepair.Various cytokines play a role in the inflammatory response after craniocerebral trauma and exhibit a significant correlation with the severity of the injury and the prognosis.This review analyzes the mechanisms and expression of different inflammatory factors following traumatic brain injury,as well as their utility as biomarkers for prognosis and treatment.The findings aim to identify suitable cytokine targets for inflammatory-targeted therapies to improve the outcomes for patients with traumatic brain injuries.

关 键 词：颅脑创伤 炎症 标志物 细胞因子类 综述 

分 类 号：R73[医药卫生—肿瘤]