肝纤维化发生和发展过程中肝脏巨噬细胞组成及其作用机制的研究进展  

Research progress on the mechanistic role and constituents of hepatic macrophages during the occurrence and development of hepatic fibrosis

作　　者：刘睿茜 刘金芳 徐平 Liu Ruixi;Liu Jinfang;Xu Ping(State Key Laboratory of Medical Proteomics,Beijing Proteome Research Center,National Center for Protein Sciences(Beijing),Beijing Institute of Lifeomics,Beijing 102206,China;Wuhan University Taikang Medical School(School of Basic Medical Sciences),Wuhan University,Wuhan 430071,China;Research Unit of Proteomics&Research and Development of New Drug,Chinese Academy of Medical Sciences,Beijing 102206,China)

机构地区：[1]军事科学院军事医学研究院、医学蛋白质组全国重点实验室国家蛋白质科学中心(北京)北京蛋白质组研究中心,北京102206 [2]武汉大学泰康医学院(基础医学院),武汉430071 [3]中国医学科学院蛋白质组学与药物研发新技术创新单元,北京102206

出　　处：《中华肝脏病杂志》2025年第2期198-204,共7页Chinese Journal of Hepatology

基　　金：国家自然科学基金青年项目(32101190);京津冀基础研究合作专项(J200001);中国医学科学院医学与健康科技创新工程项目资助(2019-I2M-5-017)。

摘　　要：巨噬细胞是肝纤维化进程中的关键细胞,参与肝纤维化各个阶段,既能促进肝纤维化的进展,又能促进肝纤维化的消退,因此鉴定肝内关键巨噬细胞亚型对于肝纤维化的治疗具有重要意义。该文根据巨噬细胞的炎症表型、来源、表面标志物和对纤维化发生的作用等方面总结了巨噬细胞的分型及功能;介绍了利用单细胞测序技术揭示的在肝纤维化发生和发展过程中新的巨噬细胞亚型及作用方式;分析了传统抗纤维化治疗的局限性,以及靶向巨噬细胞疗法的优势,为肝纤维化中新巨噬细胞亚型研究提供新的思路。Macrophages are the key cells in the process of hepatic fibrosis.Therefore,they promote the progression and regression of liver fibrosis by participating in all stages.The treatment of liver fibrosis is significantly identified by the main subtypes of intrahepatic macrophages.This article summarizes the types and functions of macrophages according to the inflammatory phenotype,origin,and surface markers and their effect on fibrosis;introduces the new subtypes and mode of action in the occurrence and development of hepatic fibrosis,as revealed by the single-cell sequencing technique;and analyzes the limitations of traditional antifibrotic therapy and the advantages of macrophage-targeting therapeutics,which could indicate the new direction for the study of new macrophage subtypes in hepatic fibrosis.

关 键 词：肝纤维化 巨噬细胞 单细胞转录组测序 抗纤维化 治疗 

分 类 号：R73[医药卫生—肿瘤]