FoxP3与PTC病理学特征及术后转移复发的关系  

The relationship between FoxP3 and pathological features of PTC and postoperative metastasis and recurrence

作　　者：刘庆华[1] 陈晓晓 任正君 LIU Qinghua;CHEN Xiaoxiao;REN Zhengjun(Thyroid and Breast Surgery Department of Puyang People's Hospital,Puyang,Henan,China,457001)

机构地区：[1]濮阳市人民医院甲状腺乳腺外科,河南濮阳457001

出　　处：《分子诊断与治疗杂志》2025年第3期417-420,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(2021063229)。

摘　　要：目的探讨甲状腺乳头状癌(PTC)组织中的FoxP3蛋白表达与肿瘤发生发展及术后转移复发的关系。方法选取濮阳市人民医院病理中心收集的96例PTC术后标本、50例符合要求的甲状腺癌癌旁组织作为对照组,采用免疫组化染色检测两组标本中的FoxP3蛋白表达,分析FoxP3蛋白在不同年龄、性别、TNM分期、是否发生周围浸润转移、是否发生淋巴结转移、不同病灶直径、不同的肿瘤病灶数目患者中的表达差异,5年随访是否复发患者中FoxP3蛋白的表达差异。结果PTC组FoxP3蛋白阳性表达率高于对照组,差异有统计学意义(P<0.05);TNM分期、是否发生周围组织浸润、是否发生淋巴结转移、不同病灶直径的肿瘤组织比较,差异均具有统计学意义(P<0.05);经过5年随访,共有24例患者出现术后复发、7例患者出现转移;PTC患者的TNM分期增高、术前发生周围组织浸润转移、术前发生淋巴结转移、FoxP3蛋白阳性表达是PTC患者术后5年出现复发或转移的独立危险因素(P<0.05)。结论PTC组织中的FoxP3蛋白表达上调与肿瘤的发生及进展有关,同时影响PTC患者术后的复发及转移。Objective To investigate the relationship between FoxP3 protein expression in thyroid papillary carcinoma(Papillary thyroid carcinoma,PTC)and tumorigenesis and postoperative metastasis.Methods Immunohistochemical staining was used to detect FoxP3 protein expression in 96 PTC postoperative specimens and 50 paracancerous thyroid tissues collected from the Pathological Center of Puyang People's Hospital,serving as the control group.The expression of FoxP3 protein was analyzed in patients of different ages and sexes,different TNM stages,presence of peripheral invasion and metastasis,lymph node metastasis,lesion diameter,and number of tumor lesions.Additionally,the expression of the FoxP3 protein was different or not in patients with recurrence during 5-year follow-up.Results The positive expression rate of FoxP3 protein in the PTC group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There were also significant differences in TNM stage,peripheral tissue infiltration,lymph node metastasis,and tumor tissues with different focal diameters(P<0.05).After a 5 years follow-up,24 patients experienced postoperative recurrence and 7 patients had metastasis.Factors such as increased TNM stage,peripheral tissue infiltration,and metastasis before surgery,as well as lymph node metastasis before surgery,and positive expression of FoxP3 protein in PTC patients were identified as independent risk factors for recurrence or metastasis 5 years after surgery(P<0.05).Conclusion The upregulation of FoxP3 protein expression in PTC tissue is related to the development and progression of tumors,and influencing the postoperative recurrence and metastasis in patients with PTC.

关 键 词：甲状腺乳头状癌 FoxP3蛋白 转移 复发 

分 类 号：R73[医药卫生—肿瘤]