溃疡性结肠炎患者血清IL-33、ANCA-IgG、IL-6水平的变化及临床意义  

Changes and clinical significance of serum IL-33,ANCA-IgG and IL-6 levels in patients with ulcerative colitis

作　　者：王文峰 黄亮 魏嫦 WANG Wenfeng;HUANG Liang;WEI Chang(Department of Gastroenterology,Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine,Zhuhai,Guangdong,China,519000)

机构地区：[1]珠海市中西医结合医院消化内科,广东珠海519000

出　　处：《分子诊断与治疗杂志》2025年第3期499-502,511,共5页Journal of Molecular Diagnostics and Therapy

基　　金：珠海市科技创新局项目(ZH22036201210139PWC)。

摘　　要：目的分析溃疡性结肠炎(UC)患者血清白细胞介素-33(IL-33)、抗中性粒细胞胞质抗体-免疫球蛋白G(ANCA-IgG)、白细胞介素-6(IL-6)水平在疾病中的变化及临床意义。方法选取2021年1月至2024年1月期间珠海市中西医结合医院消化内科就诊的114例老年UC患者作为UC组,根据患者的病情活动度分为缓解期组22例和活动期组92例(其中轻度组25例,中度组39例,重度组28例),选取同期其他肠道疾病患者61例为其他肠道疾病组。比较各组血清IL-33、ANCA-IgG、IL-6水平变化,并进行多因素分析影响UC发生的相关因素;采用受试者工作特征(ROC)曲线分析三者联合检测对UC患者的诊断效能。结果UC组的IL-33、ANCA-IgG、IL-6水平高于其他肠道疾病组(P<0.05),UC组有肠壁淋巴结肿大的比例显著高于其他肠道疾病组(P<0.05);UC组不同病情活动度中IL-33、ANCA-IgG、IL-6水平:重度组>中度组>轻度组>缓解期组(P<0.05);多因素分析显示,IL-33、ANCA-IgG、IL-6水平升高及有肠壁淋巴结肿大是影响发生UC的独立危险因素(P<0.05)。ROC曲线分析显示,IL-33、ANCA-IgG、IL-6三者联合检测的曲线下面积(AUC)为0.944,联合预测敏感度、特异度为89.5%、91.8%,高于单独检测(P<0.05)。结论血清IL-33、ANCA-IgG、IL-6水平变化与UC的发生发展相关,三者在UC患者中均升高水平,联合检测以上指标能提高UC的诊断效能,可为临床诊断UC提供有力参考。Objective To evaluate the alterations in blood levels of interleukin-6(IL-6),antineutrophil cytoplasmic antibody-immunoglobulin G(ANCA-IgG),and interleukin-33(IL-33)in ulcerative colitis(UC)patients,as well as their clinical importance.Methods The UC group consisted of 114 senior patients with UC who were hospitalized at Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine's Department of Gastroenterology between January 2021 and January 2024.The patients were divided into two groups based on the severity of their disease:the remission group(n=22)and the active group(n=92),which included the mild group(n=25),the moderate group(n=39),and the severe group(n=28).The group for other intestinal disorders consisted of 61 patients who had been diagnosed within the same time.A correlation analysis was performed and the changes in each group's serum levels of IL-33,ANCA-IgG,and IL-6 were compared.Multivariate analysis was used to examine the associated factors that impact the incidence of UC.The combined detection of the three markers in UC patients was analyzed for diagnostic effectiveness using the receiver operating characteristic(ROC)curve.Results IL-33,ANCA-IgG,and IL-6 levels were higher in the UC group than in the other disease groups(P<0.05).The proportion of intestinal wall lymph node enlargement in the UC group was significantly higher than that in the other intestinal diseases group(P<0.05).IL-33,ANCA-IgG,and IL-6 levels in patients with different disease activity in the UC group:severe group>moderate group>mild group>remission group(P<0.05).Multivariate analysis showed that elevated levels of IL-33,ANCA-IgG,IL-6,and intestinal wall lymph node enlargement were independent risk factors for UC(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of combined detection of IL-33,IL-6,and ANCA-IgG was 0.944,and the sensitivity and specificity of combined prediction were 89.5% and 91.8%,respectively,which were higher than those of single detection(P<0.05).Conclusion Changes in blood le

关 键 词：溃疡性结肠炎 白细胞介素-33 抗中性粒细胞胞质抗体 免疫球蛋白G 白细胞介素-6 

分 类 号：R73[医药卫生—肿瘤]