静脉溶栓联合介入治疗在急性脑梗死患者中的应用效果分析  

Analysis of Application Effect of Intravenous Thrombolysis Combined with Interventional Therapy in Patients with Acute Cerebral Infarction

作　　者：刘近涛 段作伟 Liu Jintao;Duan Zuowei(China General Hospital of Xuzhou Coal Mining Group(Jiawang Campus),Xuzhou 221011,Jiangsu Province,China;General Hospital of Xuzhou Coal Mining Group,Xuzhou 221011,Jiangsu Province,China)

机构地区：[1]徐州矿务集团总医院(贾汪院区),江苏徐州221011 [2]徐州矿务集团总医院,江苏徐州221011

出　　处：《中国社区医师》2025年第8期42-44,共3页Chinese Community Doctors

摘　　要：目的:分析静脉溶栓联合介入治疗在急性脑梗死(ACI)患者中的应用效果。方法:选取2021年1月—2024年9月徐州矿务集团总医院(贾汪院区)及徐州矿务集团总医院收治的ACI患者100例作为研究对象,随机分为静脉溶栓组(n=70)和联合治疗组(n=30)。静脉溶栓组实施静脉溶栓治疗,联合治疗组在静脉溶栓组基础上实施介入治疗。比较两组治疗效果。结果:治疗后,两组美国国立卫生院卒中量表、改良Rankin量表评分降低,且联合治疗组低于静脉溶栓组(P<0.05);两组Alberta卒中项目早期CT评分升高,且联合治疗组高于静脉溶栓组(P<0.05)。联合治疗组治疗总有效率高于静脉溶栓组(P=0.024)。治疗后,两组脑钠肽、神经元特异性烯醇化酶水平降低,且联合治疗组低于静脉溶栓组(P<0.05);两组神经生长因子水平升高,且联合治疗组高于静脉溶栓组(P<0.05)。两组并发症总发生率比较,无统计学差异(P>0.05)。结论:静脉溶栓联合介入治疗在ACI患者中的应用效果显著,可改善神经功能和血液学指标,且安全性较高。Objective:To analyze the application effect of intravenous thrombolysis combined with interventional therapy in patients with acute cerebral infarction(ACI).Methods:A total of 100 patients with ACI who were admitted to China General Hospital of Xuzhou Coal Mining Group(Jiawang Campus)and China General Hospital of Xuzhou Coal Mining Group from January 2021 to September 2024 were selected as the study subjects.They were randomly divided into intravenous thrombolysis group(n=70)and combination therapy group(n=30).The intravenous thrombolysis group received intravenous thrombolysis therapy,while the combination therapy group received interventional therapy on the basis of intravenous thrombolysis group.The treatment effects were compared between the two groups.Results:After treatment,the scores of National Institutes of Health Stroke Scale and Modified Rankin Scale in the two groups decreased,and the scores in the combination therapy group were lower than those in the intravenous thrombolysis group(P<0.05).The Alberta Stroke Program Early CT Score in the two groups increased,and the score in the combination therapy group was higher than that in the intravenous thrombolysis group(P<0.05).The total effective rate of therapy in the combination therapy group was higher than that in the intravenous thrombolysis group(P=0.024).After treatment,the levels of brain natriuretic peptide and neuron-specific enolase in the two groups decreased,and the levels in the combination therapy group were lower than those in the intravenous thrombolysis group(P<0.05).The levels of nerve growth factor in the two groups increased,and the levels in the combination therapy group were higher than those in the intravenous thrombolysis group(P<0.05).There was no statistical difference in the overall incidence of complications between the two groups(P>0.05).Conclusion:The application of intravenous thrombolysis combined with interventional therapy in ACI patients has a significant effect,which can improve neurological function and hematological in

关 键 词：静脉溶栓 介入治疗 急性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]