血细胞计数与急性缺血性卒中静脉溶栓后预后的研究进展  

Research progress of blood cell count in predicting the prognosis of acute ischemic stroke after intravenous thrombolysis

作　　者：彭贾贾 刘子旋 张艳吉 郭元敏 闫寒冰[1] 何晖[1] PENG Jiajia;LIU Zixuan;ZHANG Yanji(Department of Hematology,Benxi Central Hospital,Liaoning,Benxi 117000,China)

机构地区：[1]中国医科大学本溪市中心医院血液内科,辽宁省本溪市117000

出　　处：《河北医药》2025年第3期467-471,477,共6页Hebei Medical Journal

基　　金：辽宁省民生科技计划项目(编号:2021JH2/10300044)。

摘　　要：急性缺血性卒中(acute ischemic stroke,AIS)具有发病率高、致残率高以及死亡率高的特征。静脉溶栓是指南推荐的治疗急性缺血性卒中的有效方式,但很大一部分患者在静脉溶栓治疗后功能结局较差。考虑到急性缺血性卒中过程的炎症性质血细胞计数对急性缺血性卒中溶栓后近期预后有预测价值。本文综述中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)、嗜酸性粒细胞与单核细胞比值(eosinophil to monocyte ratio,EMR)、淋巴细胞与单核细胞比值(lymphocyte to monocyte ratio,LMR)、血小板与中性粒细胞比值(platelet to neutrophil ratio,PNR)等常见血细胞计数指标在AIS患者静脉溶栓后近期预后判定的作用,及其潜在的临床应用价值。Acute ischemic stroke(AIS)is characterized by high morbidity,disability and mortality.Intravenous thrombolysis(IVT)is recommended as an effective treatment for AIS,but a large proportion of patients have poor functional outcomes after IVT.Considering the potential of inflammatory blood cell count during the process of AIS in predicting the short-term prognosis of AIS,this article reviewed the role of common blood cell count indicators,including the neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),eosinophil-to-monocyte ratio(EMR),lymphocyte-to-monocyte ratio(LMR),and platelet-to-neutrophil ratio(PNR),in the short-term prognosis of AIS patients after IVT,and their potential clinical application value.

关 键 词：急性缺血性卒中 静脉溶栓 预后 血细胞计数 

分 类 号：R743.33[医药卫生—神经病学与精神病学]