胎儿颈部透明软组织厚度联合血清学指标对胎儿染色体异常与异常妊娠的诊断价值  

The diagnostic value of fetal nuchal translucency combined with serological indicators for fetal chromosomal abnormalities and abnormal pregnancy

作　　者：陈旭光 曾庆新 周文君 张瑶 蔡颖娟 CHEN Xuguang;ZENG Qingxin;ZHOU Wenjun;ZHANG Yao;CAI Yingjuan(Department of Ultrasound Medicine,Longnan First People's Hospital,Ganzhou,Jiangxi,341700,China;Department of Ultrasound Medicine,First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi,341000;Clinical Laboratory,Longnan First People's Hospital,Ganzhou,Jiangxi,341700,China)

机构地区：[1]龙南市第一人民医院超声医学科,江西赣州341700 [2]赣南医科大学第一附属医院超声医学科,江西赣州341000 [3]龙南市第一人民医院检验科,江西赣州341700

出　　处：《当代医学》2024年第36期92-95,共4页Contemporary Medicine

基　　金：赣州市科技计划项目(GZ2021ZSF540)。

摘　　要：目的分析胎儿颈部透明软组织厚度(nuchal translucency,NT)联合妊娠相关血浆蛋白A(pregnancy-associated plasma protein A,PAPPA)及孕妇游离β-人绒毛膜促性腺激素(β-human chorionic gonadotropin,β-hCG)检测对胎儿染色体异常与异常妊娠的诊断价值。方法选取2021年3月至2022年9月龙南市第一人民医院收治的68名孕早期孕妇作为研究对象,所有孕妇均行NT超声检查与血清学指标(PAPP-A、β-hCG)检测。以羊水穿刺检查结果为金标准,比较胎儿染色体正常与异常孕妇胎儿NT、PAPP-A与β-hCG水平,并分析NT超声检查、PAPP-A与β-hCG检测及联合检测对胎儿染色体异常情况的诊断效能。结果胎儿染色体正常孕妇胎儿NT薄于胎儿染色体异常孕妇,PAPP-A水平高于胎儿染色体异常孕妇,β-hCG水平低于胎儿染色体异常孕妇,差异有统计学意义(P<0.05)。胎儿NT超声检查联合血清学指标检测诊断的灵敏度高于NT超声检查、血清学指标检测,差异有统计学意义(P<0.017)。结论在胎儿染色体异常筛查与孕妇异常妊娠诊断中,胎儿NT联合孕妇PAPP-A及β-hCG检测具有良好的诊断效能。Objective To analyze diagnostic value of nuchal translucency(NT)combined with pregnancy-associated plasma protein A(PAPP-A)and maternal freeβ-human chorionic gonadotropin(β-hCG)in fetal chromosomal abnormalities and abnormal pregnancy.Methods 68 early pregnant women admitted to the Longnan First People's Hospital from March 2021 to September 2022 were selected as the research subjects,all pregnant women underwent NT ultrasound examination and serological indicators(PAPP-A,β-hCG)testing.Took the results of amniocentesis examination as the gold standard,the fetal NT,PAPP-A andβ-hCG levels were compared between pregnant women with normal and abnormal fetal chromosomes,and analyze the diagnostic efficacy of NT ultrasound examination,PAPP-A andβ-hCG detection and combined detection for fetal chromosomal abnormalities was analyzed.Results The fetal NT value in pregnant women with normal fetal chromosome was thinner than that in pregnant women with abnormal fetal chromosome,the PAPP-A level was higher than that in pregnant women with abnormal fetal chromosome,and theβ-hCG level was lower than that in pregnant women with abnormal fetal chromosome,the differences were statistically significant(P<0.05).The diagnostic sensitivity of fetal NT ultrasound combined with serological index detection method was higher than that of NT ultrasound and serological index detection,and the differences were statistically significant(P<0.017).Conclusion Fetal NT combined with PAPP-A andβ-hCG detection of pregnant women has good diagnostic efficacy in fetal chromosome abnormality screening and abnormal pregnancy diagnosis.

关 键 词：胎儿颈部透明软组织厚度 妊娠相关血浆蛋白A 游离β-人绒毛膜促性腺激素 胎儿染色体异常 

分 类 号：R71[医药卫生—妇产科学]