阿伐曲泊帕联合重组人白细胞介素-11在妇科肿瘤化疗致血小板减少症患者中的应用效果  

Application effect of avatrombopag combined with recombinate human interleukin-11 in patients with chemotherapy-induced thrombocytopenia in gynecological tumors

作　　者：杜玉丹 李玉巧 吴传欢 DU Yudan;LI Yuqiao;WU Chuanhuan(Department of Three Families of Women,Jiujiang Maternal and Child Health Care Hospital,Jiujiang,Jiangxi,332000,China)

机构地区：[1]九江市妇幼保健院妇三科,江西九江332000

出　　处：《当代医学》2024年第36期112-115,共4页Contemporary Medicine

摘　　要：目的探讨阿伐曲泊帕联合重组人白细胞介素-11在妇科肿瘤化疗致血小板减少症患者中的应用效果。方法选取2020年6月至2022年9月九江市妇幼保健院收治的80例妇科肿瘤化疗致血小板减少症患者作为研究对象,按照随机数字表法分为观察组与对照组,每组40例。对照组接受重组人白细胞介素-11治疗,观察组接受阿伐曲泊帕联合重组人白细胞介素-11治疗。比较两组血小板计数恢复时间、血小板计数变化情况、凝血功能[凝血酶原时间(prothrombin time,PT)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶时间(thrombin time,TT)、纤维蛋白原(fibrinogen,Fg)]及不良反应发生情况。结果观察组血小板计数升高至50×10^(9)/L、75×10^(9)/L、100×10^(9)/L时间均短于对照组,差异有统计学意义(P<0.05)。观察组血小板计数开始升高时间短于对照组,血小板计数最高值高于对照组,差异有统计学意义(P<0.05);两组血小板计数最低值比较差异无统计学意义。治疗后,两组PT、APTT、TT均短于治疗前,Fg水平均高于治疗前,且观察组PT、APTT、TT均短于对照组,Fg水平高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论阿伐曲泊帕联合重组人白细胞介素-11治疗妇科肿瘤所致的血小板减少症,能加快血小板生成,增强疗效且安全性较好。Objective To explore the application effect of avatrombopag combined with recombinate human interleukin-11 in patients with chemotherapy-induced thrombocytopenia in gynecological tumors.Methods A total of 80 patients with chemotherapy-induced thrombocytopenia in gynecological tumors admitted to Jiujiang Maternal and Child Health Care Hospital from June 2020 to September 2022 were selected as the study subjects,and they were divided into the observation group and the control group according to the random number table method,with 40 cases in each group.The control group was treated with recombinate human interleukin-11,and the observation group was treated with avatrombopag combined with recombinate human interleukin-11.The platelet recovery time,platelet value change,coagulation function(prothrombin time[PT],activated partial thromboplastin time[APTT],thrombin time[TT],fibrinogen[Fg])and adverse reactions were compared between the two groups.Results The time of platelet elevation to 50×10^(9)/L,75×10^(9)/L,100×10^(9)/L in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The time of platelet elevation in the observation group was shorter than that in the control group,and the maximum platelet value was higher than that in the control group,and the differences were statistically significant(P<0.05);there was no significant difference in the minimum platelet values between the two groups.After treatment,the PT,APTT and TT of the two groups were lower than those before treatment,and the Fg level of the two groups were higher than before treatment,and the PT,APTT and TT in the observation group were lower than those in the control group,and the Fg level was higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Avatropexpa combined with recombinant human interleukin-11 in the treatment of gyne

关 键 词：血小板减少症 妇科肿瘤 化疗 阿伐曲泊帕 重组人白细胞介素-11 凝血功能 血小板 

分 类 号：R73[医药卫生—肿瘤]