不同程度非酒精性脂肪性肝病患者的改良磁共振肝脏脂肪定量指标及肝转氨酶特征及相关性分析  

Analyze the characteristics and correlation of modified magnetic resonance liver fat quantitative index and liver transaminase in patients with different degrees of nonalcoholic fatty liver disease

作　　者：周斌 余惊 杨恒 殷宗云 王箭淼 殷冬林 何刘鑫 ZHOU Bin;YU Jing;YANG Heng;YIN Zongyun;WANG Jianmiao;YIN Donglin;HE Liuxin(Department of Imaging,Jiujiang Hospital of Traditional Chinese Medicine,Jiujiang,Jiangxi,332000,China)

机构地区：[1]九江市中医医院影像科,江西九江332000

出　　处：《当代医学》2024年第36期168-172,共5页Contemporary Medicine

基　　金：江西省卫生健康委科技计划(202311598)。

摘　　要：目的分析不同程度非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患者的改良磁共振肝脏脂肪定量指标及肝转氨酶特征及相关性分析。方法选取2022年10月至2023年10月于九江市中医医院肝病科门诊诊治的60例NAFLD患者作为研究对象,均行改良磁共振及肝转氨酶检查,并行常规肝脏细针穿刺明确病理分级,分析不同病理分级患者肝转氨酶[谷氨酰转肽酶(glutamyl transpeptidase,GGT)、谷草转氨酶(aspartate aminotransferase,AST)及谷丙转氨酶(alanine aminotransferase,ALT)]及改良磁共振肝脏脂肪定量指标特征(脂肪百分数、L/S CT值、肝脏脂肪含量)及相关性。结果60例患者中,F0级3例(5.00%),F1级10例(16.67%),F2级11例(18.33%),F3级20例(33.33%),F4级16例(26.67%)。F0~F4分级患者的GGT、AST、ALT水平呈逐渐升高趋势,差异有统计学意义(P<0.05)。F0~F4分级患者的脂肪百分数、L/S CT值呈逐渐升高趋势,肝脏脂肪含量呈逐渐降低趋势(P<0.05)。相关性分析结果显示,脂肪百分数、L/S CT值与GGT、AST、ALT呈正相关(r>0,P<0.05),肝脏脂肪含量与GGT、AST、ALT呈负相关(r<0,P<0.05)。结论肝转氨酶与改良磁共振肝脏脂肪定量进行监测NAFLD患者,可较为准确地评估患者的病情严重程度,且磁共振脂肪百分数与血清学检测密切相关,可为NAFLD诊断和治疗提供一定的参考依据。Objective To analyze the characteristics and correlation of modified magnetic resonance liver fat quantitative index and liver transaminase in patients with different degrees of nonalcoholic fatty liver disease(NAFLD).Methods 60 patients with NAFLD who were diagnosed and treated in the outpatient department of liver disease department of Jiujiang Hospital of Traditional Chinese Medicine from October 2022 to October 2023 were selected as the research subjects,all patients underwent modified magnetic resonance imaging and liver transaminase examination,and routine liver fine needle puncture was performed to determine the pathological grade.Liver transaminase(glutamyl transpeptidase[GGT],aspartate aminotransferase[AST]and alanine aminotransferase[ALT])and modified magnetic resonance liver fat quantitative index characteristics(fat percentage,L/S CT value,liver fat content)and correlation in patients with different pathological grades were analyzed.Results Among the 60 patients,there were 3 cases(5.0%)of F0 grade,10 cases(16.67%)of F1 grade,11 cases(18.33%)of F2 grade,20 cases(33.33%)of F3 grade and 16 cases(26.67%)of F4 grade.The levels of GGT,AST and ALT in patients with F0-F4 grade gradually increase trend,and the difference was statistically significant(P<0.05).The fat percentage and L/S CT value of patients with F0-F4 classification showed a gradual increase trend,and the liver fat content showed a gradual decrease trend(P<0.05).Correlation analysis showed that fat percentage and L/S CT value were positively correlated with GGT,AST and ALT(r>0,P<0.05),and liver fat content was negatively correlated with GGT,AST and ALT(r<0,P<0.05).Conclusion Liver transaminase and modified magnetic resonance liver fat quantitative monitoring of NAFLD patients can accurately assess the severity of the patient's condition,and the percentage of magnetic resonance fat is closely related to serological detection,which can provide a certain reference for the diagnosis and treatment of NAFLD.

关 键 词：肝脏脂肪定量 非酒精性脂肪性肝病 磁共振成像 肝转氨酶 

分 类 号：R57[医药卫生—消化系统]