食管癌新辅助治疗后手术时机的现状和进展  

Current Situation and Progress of Timing of Surgery after Neoadjuvant Therapy for Esophageal Cancer

作　　者：刘光源[1] 韩泳涛[1] LIU Guangyuan;HAN Yongtao(Sichuan Cancer Hospital&Institute,Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu,China,610041)

机构地区：[1]四川省肿瘤医院,四川省癌症防治中心,电子科技大学附属肿瘤医院,四川成都610041

出　　处：《食管疾病》2025年第1期53-58,共6页Journal of Esophageal Diseases

摘　　要：目的局部晚期食管癌患者经过新辅助治疗后会间隔一段时间再进行根治性手术,目的是让肿瘤在间隔的时间内更好地退缩,提高R0切除率及病理完全缓解率,改善生存期。其次,让术前治疗的毒性反应等状况得到最大程度的改善,降低围手术期并发症的发生率。但是,手术间隔时间过长,会增加肿瘤细胞增殖扩散的风险,而肿瘤退缩后形成的纤维瘢痕,则增加了手术的操作难度。手术的最佳时机并无定论,本文回顾分析相关文献及研究,对新辅助治疗后手术时机的选择进行阐述,期望能为临床工作提供参考和进一步研究提供依据,提高食管癌患者的生存获益。Followed by neoadjuvant therapy,patients with locally advanced esophageal cancer will undergo radical surgical resection after a time interval,which is mainly to allow the tumor regression within it,to increase the R0 resection rate,pathological complete response rate and long-term survival.Secondly,a certain interval of time can maximize the recovery from toxicities caused by preoperative therapy and reduce the incidence of perioperative complications.However,a long interval before operation will increase the risk of tumor cell proliferation and metastasis,and the continuous fibrosis after tumor regression will increase the difficulty of surgery.The optimal timing of surgery is inconclusive.This article reviews and analyzes relevant literature and research,and elaborates on the selection of surgical timing after neoadjuvant therapy,hoping to provide reference for clinical work and further research,thereby improving the survival benefits of esophageal cancer patients.

关 键 词：食管癌 新辅助放化疗 新辅助化疗 手术时机 总生存期 病理完全缓解 免疫治疗 

分 类 号：R735.1[医药卫生—肿瘤]