外周血CTLA-4、PD-1、BTLA表达与中晚期肝癌病理特征及预后的关系  

Relationship between expression of CTLA-4,PD-1,and BTLA in periph⁃eral blood and pathological characteristics and prognosis on moderate and advanced liver cancer

作　　者：陆小华[1] 袁洪新[1] LU Xiao-hua;YUAN Hong-xin(Department of Interventional and Vascular Surgery,Affiliated Hospital of Nantong University,Nantong 226001,China)

机构地区：[1]南通大学附属医院介入与血管外科,江苏南通226001

出　　处：《中国现代普通外科进展》2025年第3期191-195,共5页Chinese Journal of Current Advances in General Surgery

基　　金：江苏省南通市科技局2021基础科学研究公众健康项目(JC2021196)。

摘　　要：目的:观察外周血细胞毒性T淋巴细胞抗原-4(CTLA-4)、程序性死亡受体-1(PD-1)、T淋巴细胞弱化因子(BTLA)表达与中晚期肝癌患者病理特征及预后的关系。方法:选取120例中晚期肝癌患者、120例体检者分别作为肝癌组、对照组。比较两组及肝癌组不同临床病理特征的CTLA-4、PD-1、BTLA水平,分析外周血各指标与临床病理特征的相关性;肝癌组随访2年根据患者预后分为预后良好、预后不良,比较不同预后患者各指标表达情况,分析外周血各指标不同表达与中晚期肝癌预后生存的关系及联合检测的预测价值。结果:肝癌组外周血CTLA-4、PD-1、BTLA mRNA水平高于对照组(P<0.05);肝癌组不同肿瘤数目、分化程度、临床分期、肿瘤大小、血管侵犯患者外周血CTLA-4、PD-1、BTLA mRNA水平比较差异有统计学意义(P<0.05);外周血CTLA-4、PD-1、BTLA mRNA水平与肿瘤数目、分化程度、临床分期、血管侵犯呈正相关(P<0.05);中晚期肝癌预后不良患者外周血CTLA-4、PD-1、BTLA mRNA高于预后良好患者(P<0.05);外周血CTLA-4、PD-1、BTLA mRNA联合预测中晚期肝癌预后的AUC为0.935;高表达CTLA-4、PD-1、BTLA mRNA中晚期肝癌患者总生存率低于低表达CTLA-4、PD-1、BTLA mRNA中晚期肝癌患者(P<0.05)。结论:外周血CTLA-4、PD-1、BTLA表达与中晚期肝癌患者病理特征、预后有关,其联合预测患者预后价值较高。Objective:To observe the relationship between the expression of cytotoxic T lymphocyte antigen-4(CTLA-4),programmed death receptor-1(PD-1),and T lymphocyte attenuator(BTLA)in peripheral blood cells and the pathological characteristics and prognosis of patients with moderate and advanced liver cancer.Methods:A total of 120 patients with moderate and advanced liver cancer and 120 physical examination subjects admitted to our hospital were selected as the liver cancer group and control group.The levels of CTLA-4,PD-1,and BTLA in the two groups and dif-ferent clinical pathological characteristics of the liver cancer group were compared,and the correlation between periph-eral blood indicators and clinical pathological characteristics was analyzed;The liver cancer group was followed up for 2 years and divided into poor prognosis and good prognosis groups based on prognosis.The expression of various indica-tors in patients with different prognoses was compared,and the predictive value of peripheral blood indicators combined for the prognosis and survival relationship of advanced liver cancer was analyzed.Result:The levels of CTLA-4,PD-1,and BTLA mRNA in the peripheral blood of the liver cancer group were higher than those in the control group(P<0.05);Comparison of peripheral blood CTLA-4,PD-1 and BTLA mRNA levels in patients with different tumour numbers,differ-entiation,clinical stage,tumour size and vascular invasion in the liver cancer group,there were statistically significant dif-ferences(P<0.05);the levels of CTLA-4,PD-1,and BTLA mRNA in peripheral blood were positively correlated with tu-mor number,differentiation degree,clinical stage,and vascular invasion(P<0.05);the mRNA levels of CTLA-4,PD-1,and BTLA in peripheral blood of patients with poor prognosis in moderate and advanced liver cancer were higher than those of patients with good prognosis(P<0.05);the AUC of peripheral blood CTLA-4,PD-1,and BTLA mRNA combined to predict the prognosis of moderate and advanced liver cancer was 0.935;the overall survival rate

关 键 词：中晚期肝癌 外周血 细胞毒性T淋巴细胞抗原-4 程序性死亡受体-1 T淋巴细胞弱化因子 预后 

分 类 号：R735.7[医药卫生—肿瘤]