Repetitive Transcranial Magnetic Stimulation(rTMS)Improves Cognitive Impairment and Intestinal Microecological Dysfunction Induced by High-Fat Diet in Rats  

作　　者：Kangyu Jin Bing Chen Shengyi Han Jingyi Dong Shangping Cheng Bin Qin Jing Lu 

机构地区：[1]Department of Psychiatry,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China [2]The Key Laboratory of Mental Disorder Management in Zhejiang Province,Hangzhou 310003,China [3]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou City 310003,China [4]School of Life Sciences,Zhejiang Chinese Medical University,Hangzhou,China

出　　处：《Research》2025年第1期356-370,共15页研究(英文)

基　　金：support of funds from the National Natural Science Foundation(82271561);the Medical Science and Technology Project of Zhejiang Province(2022RC024).

摘　　要：Consuming a high-fat diet(HFD)is widely recognized to cause obesity and result in chronic brain inflammation that impairs cognitive function.Repetitive transcranial magnetic stimulation(rTMS)has shown effectiveness in both weight loss and cognitive improvement,although the exact mechanism is still unknown.Our study examined the effects of rTMS on the brain and intestinal microecological dysfunction.rTMS successfully reduced cognitive decline caused by an HFD in behavioral assessments involving the Y maze and novel object recognition.This was accompanied by an increase in the number of new neurons and the transcription level of genes related to synaptic plasticity(spindlin 1,synaptophysin,and postsynaptic protein-95)in the hippocampus.It was reached that rTMS decreased the release of high mobility group box 1,activation of microglia,and inflammation in the brains of HFD rats.rTMS also reduced hypothalamic hypocretin levels and improved peripheral blood lipid metabolism.In addition,rTMS recovered the HFD-induced gut microbiome imbalances,metabolic disorders,and,in particular,reduced levels of the microvirus.Our research emphasized that rTMS enhanced cognitive abilities,resulting in positive impacts on brain inflammation,neurodegeneration,and the microbiota in the gut,indicating the potential connection between the brain and gut,proposing that rTMS could be a new approach to addressing cognitive deficits linked to obesity.

关 键 词：behavioral assessments repetitive transcranial magnetic stimulation transcranial magnetic stimulation rtms cognitive decline cognitive impairment chronic brain inflammation 

分 类 号：R741[医药卫生—神经病学与精神病学]