A Multifunctional Nanocatalytic Metal-Organic Framework as a Ferroptosis Amplifier for Mild Hyperthermia Photothermal Therapy  

作　　者：Ying Deng Duo Wang Wenhua Zhao Guanhua Qiu Xiaoqi Zhu Qin Wang Tian Qin Jiali Tang Jinghang Jiang Ningjing Lin Lili Wei Yichen Liu Yuan Xie Jie Chen Liu Deng Junjie Liu 

机构地区：[1]Department of Medical Ultrasound,Guangxi Medical University Cancer Hospital,Guangxi Medical University,Nanning,Guangxi,China [2]Center of Interventional Radiology and Vascular Surgery,Department of Radiology,Zhongda Hospital,Medical School,Southeast University,Nanjing,Jiangsu,China [3]Department of Oncology and Research Department,Guangxi Medical University Cancer Hospital,Guangxi Medical University,Nanning,Guangxi,China [4]Department of Hepatobiliary Surgery,Guangxi Medical University Cancer Hospital,Guangxi Medical University,Nanning,Guangxi,China [5]Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science,College of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan,China

出　　处：《Research》2025年第1期517-529,共13页研究(英文)

基　　金：supported by the Postdoctoral Fellowship Program of CPSF[grant number BX20230068];the National Natural Science Foundation of China[grant numbers 82160341 and 82260345];the Natural Science Foundation of Guangxi[grant number 2022GXNSFDA035060];the China Postdoctoral Science Foundation[grant number 2023MD744192];the Key Research and Development Plan of Guangxi[grant number GUIKEAB22080066].

摘　　要：Hyperthermia therapy is considered an effective anticancer strategy.However,high temperature can trigger an excessive inflammatory response,leading to tumor self-protection,immunosuppression,metastasis,and recurrence.To address this issue,we reported a multifunctional photothermal nanoplatform to achieve mild hyperthermia photothermal therapy(mild PTT)based on cisplatin(DDP)and a ferrocene metal-organic framework(MOF-Fc)nanocomposite,which can specifically enhance ferroptosis-triggered oxidative stress levels and synchronously amplify mild hyperthermia PTT-mediated anticancer responses.Both in vitro and in vivo antineoplastic results verify the superiority of mild PTT with DDP/[e-mail] combination of DDP and MOF-Fc exhibits Fenton catalytic activity and glutathione depletion capacity,magnifying mild hyperthermia effects via the radical oxygen species(ROS)-adenosine triphosphate(ATP)-HSP silencing pathway,with important implications for clinical hyperthermia therapy.

关 键 词：hyperthermia therapy anticancer strategyhoweverhigh ferroptosis amplifier mild hyperthermia photothermal therapy multifunctional photothermal nanoplatform ferrocene metal organic framework 

分 类 号：R730.5[医药卫生—肿瘤]