Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling  

作　　者：Youxia Wang Xinmei Zhang Ifen Hung Chunxue Liu Wenkai Ren Liangpeng Ge Hao Wang 

机构地区：[1]State Key Laboratory of Livestock and Poultry Breeding,Guangdong Laboratory of Lingnan Modern Agriculture,College of Animal Science,South China Agricultural University,Guangzhou,China [2]Anyou Biotechnology Group Co.Ltd.,Taicang,China [3]Joint Laboratory of Functional Nutrition and Animal Health,Centree Bio-tech (Wuhan) Co.Ltd.,Wuhan,China [4]National Center of Technology Innovation for Pigs,Chongqing Academy of Animal Sciences,Key Laboratory of Pig Industry Science,Ministry of Agriculture,Chongqing,China [5]College of Animal Science and Veterinary Medicine,Henan Institute of Science and Technology,Xinxiang,Henan,China

出　　处：《Research》2025年第1期752-764,共13页研究(英文)

基　　金：supported by the National Natural Science Foundation of China(U22A20510 and 32225047);Laboratory of Lingnan Modern Agriculture Project(NT2021005);Double first-class discipline promotion project(2023B10564001);National Center of Technology Innovation for Pigs(NCTIP-XD/B13).

摘　　要：The prevalence of food allergies is increasing dramatically and causing serious public health concerns.Notably,melatonin metabolism imbalance in patients with food allergies;however,the role of melatonin in food allergies remains unclear.Here,we demonstrated that melatonin suppresses food allergy responses and reprograms the gut microbiota of food-allergic mice,while melatonin aggravates food allergy during gut microbiota depletion.Mechanistically,melatonin boosts the degranulation of mast cells by up-regulating the expression of membrane high-affinity immunoglobulin E(IgE)receptor(FcεRI).Melatonin increases the mRNA expression of Rabenosyn-5(a component of factors for endosome recycling and Rab interactions)through melatonin receptor 2(MT2)-extracellular signal-regulated kinase(ERK)signaling,thereby driving the recycling of FcεRI and elevating the abundance of membrane FcεRI.Likewise,the inhibition of MT2 attenuates melatonin-induced food allergy in mice with gut microbiota depletion.Collectively,our finding provides insights into the pathogenesis of food allergies and provides a potential therapeutic target for the prevention and treatment of food allergies.

关 键 词：food allergieshoweverthe degranulation mast cells reprograms gut microbiota gut microbiota food allergy aggravates food allergy suppresses food allergy MELATONIN 

分 类 号：R593.1[医药卫生—内科学] R392[医药卫生—临床医学]