Nano-Assisted Radiotherapy Strategies:New Opportunities for Treatment of Non-Small Cell Lung Cancer  

作　　者：Lihong Zhao Mei Li Chen Shen Yurui Luo Xiaoming Hou Yu Qi Ziwei Huang Wei Li Lanyang Gao Min Wu Yao Luo 

机构地区：[1]West China Hospital,Sichuan University,Chengdu 610041,China [2]The Affiliated Hospital of Southwest Medical University,Southwest Medical University,Luzhou 646000,China [3]Zigong First People's Hospital,Zigong 643000,China

出　　处：《Research》2025年第1期782-802,共21页研究(英文)

基　　金：supported by the National Natural Science Foundation of China(82003262);Science and Technology Program of Sichuan Province(2024NSFSC1922);Zigong Academy of Medical Sciences 2022(ZGYKY22KF002);Sichuan University Postdoctoral Interdisciplinary Innovation Fund;Post-Doctor Research Project,West China Hospital,Sichuan University(2021HXBH009).

摘　　要：Lung cancer is the second most commonly diagnosed cancer and a leading cause of cancer-related death,with non-small cell lung cancer(NSCLC)being the most prevalent type.Over 70%of lung cancer patients require radiotherapy(RT),which operates through direct and indirect mechanisms to treat cancer.However,RT can damage healthy tissues and encounter radiological resistance,making it crucial to enhance its precision to optimize treatment outcomes,minimize side effects,and overcome radioresistance.Integrating nanotechnology into RT presents a promising method to increase its efficacy.This review explores various nano-assisted RT strategies aimed at achieving precision treatment.These include using nanomaterials as radiosensitizers,applying nanotechnology to modify the tumor microenvironment,and employing nano-based radioprotectors and radiation-treated cell products for indirect cancer RT.We also explore recent advancements in nano-assisted RT for NSCLC,such as biomimetic targeting that alters mesenchymal stromal cells,magnetic targeting strategies,and nanosensitization with high-atomic number nanomaterials.Finally,we address the existing challenges and future directions of precision RT using nanotechnology,highlighting its potential clinical applications.

关 键 词：tumor microenvironment direct indirect mechanisms RADIOSENSITIZERS nano assisted radiotherapy healthy tissues non small cell lung cancer radiological resistancemaking enhance its precision 

分 类 号：R734.2[医药卫生—肿瘤]