基于中医理论的胃肠-脑跨器官多模态表征体系的建立及其在难治性疾病中的应用  

Establishment of a Gastrointestinal-Brain Inter-Organ Multimodal Characterization System Based on Traditional Chinese Medicine Theory and Its Application in Refractory Diseases

作　　者：韩广卉 郭艳[2] 荣培晶 丛斌[4] 刘双江[5] 李少源[6] 魏玮[1,7,8] HAN Guanghui;GUO Yan;RONG Peijing;CONG Bin;LIU Shuangjiang;LI Shaoyuan;WEI Wei(Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing,100102;Xiyuan Hospital,China Academy of Chinese Medical Sciences;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences;College of Forensic Medicine,School of Basic Medical,Hebei Medical University;State Key Laboratory of Microbial Resources,Institute of Microbiology,Chinese Academy of Sciences;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences;National Key Laboratory of Kidney Diseases;Key Research Laboratory of Brain-gut Coordination Treatment and Principles,National Administration of Traditional Chinese Medicine)

机构地区：[1]中国中医科学院望京医院,北京市朝阳区100102 [2]中国中医科学院西苑医院 [3]中国中医科学院中医临床基础医学研究所 [4]河北医科大学基础医学院法医学院 [5]中国科学院微生物研究所微生物资源前期开发国家重点实验室 [6]中国中医科学院针灸研究所 [7]肾脏疾病全国重点实验室 [8]国家中医药管理局脑肠同调治则治法重点研究室

出　　处：《中医杂志》2025年第6期561-568,共8页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(U22A20375);国家重点研发计划(2023YFC3503600);国家中医药管理局中医药创新团队及人才支持计划-国家中医药传承创新团队项目(ZYYCXTD-C-202210);中国中医科学院科技创新工程(CI2023C011YL,CI2021A01008)。

摘　　要：整体观念是中医学的核心理念,各个脏腑组织相互协调,共同维持人体生命活动,其中脾胃与中枢(脑)的关系密切且相互影响。胃肠-脑轴在消化系统和中枢神经系统之间发挥着重要的桥梁作用,通过复杂的神经、内分泌及免疫机制,实现了大脑与胃肠道之间的双向信息交流。跨器官理论涉及不同器官和系统之间的相互作用、协调与整合;多模态表征则利用视听触觉等多种感官模式传达信息。通过结合中医理论、胃肠-脑轴理论、跨器官理论和多模态表征,提出建立胃肠-脑跨器官多模态表征体系,并探讨该体系在功能性胃肠病、消化道癌前疾病、阿尔茨海默病、帕金森病、2型糖尿病、抑郁症等难治性疾病中的作用机制与应用价值。The concept of holism is the core idea of traditional Chinese medicine(TCM).Various organs and tissues coordinate with each other to maintain the body's life activities,with a close and mutual influence between the spleen,stomach,and the central nervous system(brain).The gut-brain axis plays an important bridging role between the digestive system and the central nervous system,achieving bidirectional information exchange between the brain and the gastrointestinal tract through complex neuroendocrine and immune mechanisms.The theory of cross-organ interaction involves the mutual influence,coordination,and integration between different organs and systems;multimodality,on the other hand,utilizes multiple sensory modalities,such as vision,hearing,and touch,to convey information.By combining TCM theory with the gut-brain axis theory,a cross-organ multimodal characterization system is established to explore its mechanism and application value in refractory diseases such as functional gastrointestinal disorders,precancerous gastrointestinal diseases,Alzheimer's disease,Parkinson's syndrome,type 2 diabetes,and depression.

关 键 词：胃肠-脑轴 多模态表征体系 难治性疾病 

分 类 号：R74[医药卫生—神经病学与精神病学]